Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Würtz:2016:ije/dyw175,
author = {Würtz, P and Cook, S and Wang, Q and Tiainen, M and Tynkkynen, T and Kangas, AJ and Soininen, P and Laitinen, J and Viikari, J and Kähönen, M and Lehtimäki, T and Perola, M and Blankenberg, S and Zeller, T and Männistö, S and Salomaa, V and Järvelin, MR and Raitakari, OT and Ala-Korpela, M and Leon, DA},
doi = {ije/dyw175},
journal = {International Journal of Epidemiology},
pages = {1493--1506},
title = {Metabolic profiling of alcohol consumption in 9778 young adults},
url = {http://dx.doi.org/10.1093/ije/dyw175},
volume = {45},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: High alcohol consumption is a major cause of morbidity, yet alcohol is associated with both favourable and adverse effects on cardiometabolic risk markers. We aimed to characterize the associations of usual alcohol consumption with a comprehensive systemic metabolite profile in young adults. METHODS: Cross-sectional associations of alcohol intake with 86 metabolic measures were assessed for 9778 individuals from three population-based cohorts from Finland (age 24-45 years, 52% women). Metabolic changes associated with change in alcohol intake during 6-year follow-up were further examined for 1466 individuals. Alcohol intake was assessed by questionnaires. Circulating lipids, fatty acids and metabolites were quantified by high-throughput nuclear magnetic resonance metabolomics and biochemical assays. RESULTS: Increased alcohol intake was associated with cardiometabolic risk markers across multiple metabolic pathways, including higher lipid concentrations in HDL subclasses and smaller LDL particle size, increased proportions of monounsaturated fatty acids and decreased proportion of omega-6 fatty acids, lower concentrations of glutamine and citrate (P < 0.001 for 56 metabolic measures). Many metabolic biomarkers displayed U-shaped associations with alcohol consumption. Results were coherent for men and women, consistent across the three cohorts and similar if adjusting for body mass index, smoking and physical activity. The metabolic changes accompanying change in alcohol intake during follow-up resembled the cross-sectional association pattern (R(2 )= 0.83, slope = 0.72 ± 0.04). CONCLUSIONS: Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardiometabolic risk. The metabolic signature tracks with long-term changes in alcohol consumption. These results elucidate the double-edged effects of alcohol on cardiovascula
AU  - Würtz,P
AU  - Cook,S
AU  - Wang,Q
AU  - Tiainen,M
AU  - Tynkkynen,T
AU  - Kangas,AJ
AU  - Soininen,P
AU  - Laitinen,J
AU  - Viikari,J
AU  - Kähönen,M
AU  - Lehtimäki,T
AU  - Perola,M
AU  - Blankenberg,S
AU  - Zeller,T
AU  - Männistö,S
AU  - Salomaa,V
AU  - Järvelin,MR
AU  - Raitakari,OT
AU  - Ala-Korpela,M
AU  - Leon,DA
DO  - ije/dyw175
EP  - 1506
PY  - 2016///
SN  - 1464-3685
SP  - 1493
TI  - Metabolic profiling of alcohol consumption in 9778 young adults
T2  - International Journal of Epidemiology
UR  - http://dx.doi.org/10.1093/ije/dyw175
UR  - http://hdl.handle.net/10044/1/41115
VL  - 45
ER  -
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