Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schumann:2016:10.1073/pnas.1611243113,
author = {Schumann, G and Liu, C and O'Reilly, P and Gao, H and Song, P and Xu, B and Ruggeri, B and Amin, N and Jia, T and Preis, S and Segura, Lepe M and Akira, S and Barbieri, C and Baumeister, S and Cauchi, S and Clarke, TK and Enroth, S and Fischer, K and Hällfors, J and Harris, SE and Hieber, S and Hofer, E and Hottenga, JJ and Johansson, Å and Joshi, PK and Kaartinen, N and Laitinen, J and Lemaitre, R and Loukola, A and Luan, J and Lyytikäinen, LP and Mangino, M and Manichaikul, A and Mbarek, H and Milaneschi, Y and Moayyeri, A and Mukamal, K and Nelson, C and Nettleton, J and Partinen, E and Rawal, R and Robino, A and Rose, L and Sala, C and Satoh, T and Schmidt, R and Schraut, K and Scott, R and Smith, AV and Starr, JM and Teumer, A and Trompet, S and Uitterlinden, AG and Venturini, C and Vergnaud, AC and Verweij, N and Vitart, V and Vuckovic, D and Wedenoja, J and Yengo, L and Yu, B and Zhang, W and Zhao, JH and Boomsma, DI and Chambers, J and Chasman, DI and Daniela, T and de, Geus E },
doi = {10.1073/pnas.1611243113},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
pages = {14372--14377},
title = {KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference},
url = {http://dx.doi.org/10.1073/pnas.1611243113},
volume = {113},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and replication study to date (>105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking. We found that a locus in the gene encoding β-Klotho is associated with alcohol consumption. β-Klotho is an essential receptor component for the endocrine FGFs, FGF19 and FGF21. Using mouse models and pharmacologic administration of FGF21, we show that β-Klotho in the brain controls alcohol drinking. These findings reveal a mechanism regulating alcohol consumption in humans that may be pharmacologically tractable for reducing alcohol intake.
AU  - Schumann,G
AU  - Liu,C
AU  - O'Reilly,P
AU  - Gao,H
AU  - Song,P
AU  - Xu,B
AU  - Ruggeri,B
AU  - Amin,N
AU  - Jia,T
AU  - Preis,S
AU  - Segura,Lepe M
AU  - Akira,S
AU  - Barbieri,C
AU  - Baumeister,S
AU  - Cauchi,S
AU  - Clarke,TK
AU  - Enroth,S
AU  - Fischer,K
AU  - Hällfors,J
AU  - Harris,SE
AU  - Hieber,S
AU  - Hofer,E
AU  - Hottenga,JJ
AU  - Johansson,Å
AU  - Joshi,PK
AU  - Kaartinen,N
AU  - Laitinen,J
AU  - Lemaitre,R
AU  - Loukola,A
AU  - Luan,J
AU  - Lyytikäinen,LP
AU  - Mangino,M
AU  - Manichaikul,A
AU  - Mbarek,H
AU  - Milaneschi,Y
AU  - Moayyeri,A
AU  - Mukamal,K
AU  - Nelson,C
AU  - Nettleton,J
AU  - Partinen,E
AU  - Rawal,R
AU  - Robino,A
AU  - Rose,L
AU  - Sala,C
AU  - Satoh,T
AU  - Schmidt,R
AU  - Schraut,K
AU  - Scott,R
AU  - Smith,AV
AU  - Starr,JM
AU  - Teumer,A
AU  - Trompet,S
AU  - Uitterlinden,AG
AU  - Venturini,C
AU  - Vergnaud,AC
AU  - Verweij,N
AU  - Vitart,V
AU  - Vuckovic,D
AU  - Wedenoja,J
AU  - Yengo,L
AU  - Yu,B
AU  - Zhang,W
AU  - Zhao,JH
AU  - Boomsma,DI
AU  - Chambers,J
AU  - Chasman,DI
AU  - Daniela,T
AU  - de,Geus E
AU  - Deary,I
AU  - Eriksson,JG
AU  - Esko,T
AU  - Eulenburg,V
AU  - Franco,OH
AU  - Froguel,P
AU  - Gieger,C
AU  - Grabe,HJ
AU  - Gudnason,V
AU  - Gyllensten,U
AU  - Harris,TB
AU  - Hartikainen,AL
AU  - Heath,AC
AU  - Hocking,L
AU  - Hofman,A
AU  - Huth,C
AU  - Jarvelin,MR
AU  - Jukema,JW
AU  - Kaprio,J
AU  - Kooner,JS
AU  - Kutalik,Z
AU  - Lahti,J
AU  - Langenberg,C
AU  - Lehtimäki,T
AU  - Liu,Y
AU  - Madden,PA
AU  - Martin,N
AU  - Morrison,A
AU  - Penninx,B
AU  - Pirastu,N
AU  - Psaty,B
AU  - Raitakari,O
AU  - Ridker,P
AU  - Rose,R
AU  - Rotter,JI
AU  - Samani,NJ
AU  - Schmidt,H
AU  - Spector,TD
AU  - Stott,D
AU  - Strachan,D
AU  - Tzoulaki,I
AU  - van,der Harst P
AU  - van,Duijn CM
AU  - Marques-Vidal,P
AU  - Vollenweider,P
AU  - Wareham,NJ
AU  - Whitfield,JB
AU  - Wilson,J
AU  - Wolffenbuttel,B
AU  - Bakalkin,G
AU  - Evangelou,E
AU  - Liu,Y
AU  - Rice,KM
AU  - Desrivières,S
AU  - Kliewer,SA
AU  - Mangelsdorf,DJ
AU  - Müller,CP
AU  - Levy,D
AU  - Elliott,P
DO  - 10.1073/pnas.1611243113
EP  - 14377
PY  - 2016///
SN  - 1091-6490
SP  - 14372
TI  - KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
T2  - Proceedings of the National Academy of Sciences of the United States of America
UR  - http://dx.doi.org/10.1073/pnas.1611243113
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27911795
UR  - http://hdl.handle.net/10044/1/43194
VL  - 113
ER  -
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