Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vonk:2017:10.1371/journal.pone.0172716,
author = {Vonk, JM and Scholtens, S and Postma, DS and Moffatt, MF and Jarvis, D and Ramasamy, A and Wjst, M and Omenaas, ER and Bouzigon, E and Demenais, F and Nadif, R and Siroux, V and Polonikov, AV and Solodilova, M and Ivanov, VP and Curjuric, I and Imboden, M and Kumar, A and Probst-Hensch, N and Ogorodova, LM and Puzyrev, VP and Bragina, EY and Freidin, MB and Nolte, IM and Farrall, AM and Cookson, WOCM and Strachan, DP and Koppelman, GH and Boezen, HM},
doi = {10.1371/journal.pone.0172716},
journal = {PLoS ONE},
title = {Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium},
url = {http://dx.doi.org/10.1371/journal.pone.0172716},
volume = {12},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundGenome-wide association studies have identified novel genetic associations for asthma, butwithout taking into account the role of active tobacco smoking. This study aimed to identifynovel genes that interact with ever active tobacco smoking in adult onset asthma.MethodsWe performed a genome-wide interaction analysis in six studies participating in theGABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure.We performed a discovery meta-analysis including 4,057 subjects of European descent andreplicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475subjects.ResultsFirst approach: 50 SNPs were selected based on an overall interaction effect at p<10−4. Themost pronounced interaction effect was observed for rs9969775 on chromosome 9 (discoverymeta-analysis: ORint = 0.50, p = 7.6310−5, replication: ORint = 0.65, p = 0.02). Secondapproach: 35 SNPs were selected based on the overall genetic effect in exposed subjects(p <10−4). The most pronounced genetic effect was observed for rs5011804 on chromosome12 (discovery meta-analysis ORint = 1.50, p = 1.2110−4; replication: ORint = 1.40,p = 0.03).ConclusionsUsing two genome-wide interaction approaches, we identified novel polymorphisms in nonannotatedintergenic regions on chromosomes 9 and 12, that showed suggestive evidencefor interaction with active tobacco smoking in the onset of adult asthma.
AU  - Vonk,JM
AU  - Scholtens,S
AU  - Postma,DS
AU  - Moffatt,MF
AU  - Jarvis,D
AU  - Ramasamy,A
AU  - Wjst,M
AU  - Omenaas,ER
AU  - Bouzigon,E
AU  - Demenais,F
AU  - Nadif,R
AU  - Siroux,V
AU  - Polonikov,AV
AU  - Solodilova,M
AU  - Ivanov,VP
AU  - Curjuric,I
AU  - Imboden,M
AU  - Kumar,A
AU  - Probst-Hensch,N
AU  - Ogorodova,LM
AU  - Puzyrev,VP
AU  - Bragina,EY
AU  - Freidin,MB
AU  - Nolte,IM
AU  - Farrall,AM
AU  - Cookson,WOCM
AU  - Strachan,DP
AU  - Koppelman,GH
AU  - Boezen,HM
DO  - 10.1371/journal.pone.0172716
PY  - 2017///
SN  - 1932-6203
TI  - Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0172716
UR  - http://hdl.handle.net/10044/1/54033
VL  - 12
ER  -
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