Imperial College London
Portrait Picture

PROFESSOR MIRIAM F. MOFFATT

Faculty of Medicine, National Heart & Lung Institute

Consul for the Faculty of Medicine, Professor
 
 
 
//

Contact

 

+44 (0)20 7594 2942m.moffatt

 
 
//

Location

 

400Guy Scadding BuildingRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Cuthbertson:2024:10.1038/s42003-024-05840-3,
author = {Cuthbertson, L and Löber, U and Ish-Horowicz, JS and McBrien, CN and Churchward, C and Parker, JC and Olanipekun, MT and Burke, C and McGowan, A and Davies, GA and Lewis, KE and Hopkin, JM and Chung, KF and O'Carroll, O and Faul, J and Creaser-Thomas, J and Andrews, M and Ghosal, R and Piatek, S and Willis-Owen, SAG and Bartolomaeus, TUP and Birkner, T and Dwyer, S and Kumar, N and Turek, EM and William, Musk A and Hui, J and Hunter, M and James, A and Dumas, M-E and Filippi, S and Cox, MJ and Lawley, TD and Forslund, SK and Moffatt, MF and Cookson, WOC},
doi = {10.1038/s42003-024-05840-3},
journal = {Communications Biology},
title = {Genomic attributes of airway commensal bacteria and mucosa},
url = {http://dx.doi.org/10.1038/s42003-024-05840-3},
volume = {7},
year = {2024}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Microbial communities at the airway mucosal barrier are conserved and highly ordered, in likelihood reflecting co-evolution with human host factors. Freed of selection to digest nutrients, the airway microbiome underpins cognate management of mucosal immunity and pathogen resistance. We show here the initial results of systematic culture and whole-genome sequencing of the thoracic airway bacteria, identifying 52 novel species amongst 126 organisms that constitute 75% of commensals typically present in heathy individuals. Clinically relevant genes encode antimicrobial synthesis, adhesion and biofilm formation, immune modulation, iron utilisation, nitrous oxide (NO) metabolism and sphingolipid signalling. Using whole-genome content we identify dysbiotic features that may influence asthma and chronic obstructive pulmonary disease. We match isolate gene content to transcripts and metabolites expressed late in airway epithelial differentiation, identifying pathways to sustain host interactions with microbiota. Our results provide a systematic basis for decrypting interactions between commensals, pathogens, and mucosa in lung diseases of global significance.
AU  - Cuthbertson,L
AU  - Löber,U
AU  - Ish-Horowicz,JS
AU  - McBrien,CN
AU  - Churchward,C
AU  - Parker,JC
AU  - Olanipekun,MT
AU  - Burke,C
AU  - McGowan,A
AU  - Davies,GA
AU  - Lewis,KE
AU  - Hopkin,JM
AU  - Chung,KF
AU  - O'Carroll,O
AU  - Faul,J
AU  - Creaser-Thomas,J
AU  - Andrews,M
AU  - Ghosal,R
AU  - Piatek,S
AU  - Willis-Owen,SAG
AU  - Bartolomaeus,TUP
AU  - Birkner,T
AU  - Dwyer,S
AU  - Kumar,N
AU  - Turek,EM
AU  - William,Musk A
AU  - Hui,J
AU  - Hunter,M
AU  - James,A
AU  - Dumas,M-E
AU  - Filippi,S
AU  - Cox,MJ
AU  - Lawley,TD
AU  - Forslund,SK
AU  - Moffatt,MF
AU  - Cookson,WOC
DO  - 10.1038/s42003-024-05840-3
PY  - 2024///
SN  - 2399-3642
TI  - Genomic attributes of airway commensal bacteria and mucosa
T2  - Communications Biology
UR  - http://dx.doi.org/10.1038/s42003-024-05840-3
UR  - http://hdl.handle.net/10044/1/109593
VL  - 7
ER  -
Download