Imperial College London
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DrMichelaNoseda

Faculty of Medicine, National Heart & Lung Institute

Senior Lecturer in Cardiac Molecular Pathology
 
 
 
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Contact

 

+44 (0)20 7594 9496m.noseda Website

 
 
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Location

 

431ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sungnak:2020:10.1038/s41591-020-0868-6,
author = {Sungnak, W and Huang, N and Bécavin, C and Berg, M and Queen, R and Litvinukova, M and Talavera-López, C and Maatz, H and Reichart, D and Sampaziotis, F and Worlock, KB and Yoshida, M and Barnes, JL and HCA, Lung Biological Network},
doi = {10.1038/s41591-020-0868-6},
journal = {Nat Med},
pages = {681--687},
title = {SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.},
url = {http://dx.doi.org/10.1038/s41591-020-0868-6},
volume = {26},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
AU  - Sungnak,W
AU  - Huang,N
AU  - Bécavin,C
AU  - Berg,M
AU  - Queen,R
AU  - Litvinukova,M
AU  - Talavera-López,C
AU  - Maatz,H
AU  - Reichart,D
AU  - Sampaziotis,F
AU  - Worlock,KB
AU  - Yoshida,M
AU  - Barnes,JL
AU  - HCA,Lung Biological Network
DO  - 10.1038/s41591-020-0868-6
EP  - 687
PY  - 2020///
SP  - 681
TI  - SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
T2  - Nat Med
UR  - http://dx.doi.org/10.1038/s41591-020-0868-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32327758
VL  - 26
ER  -
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