Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 6804m.stevens

 
 
//

Location

 

208Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

359 results found

Jell G, Stevens MM, 2006, Gene activation by bioactive glasses, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 17, Pages: 997-1002, ISSN: 0957-4530

Journal article

Mart RJ, Osborne RD, Stevens MM, Ulijn RVet al., 2006, Peptide-based stimuli-responsive biomaterials, SOFT MATTER, Vol: 2, Pages: 822-835, ISSN: 1744-683X

Journal article

Hahn MS, Teply BA, Stevens MM, Zeitels SM, Langer Ret al., 2006, Collagen composite hydrogels for vocal fold lamina propria restoration, BIOMATERIALS, Vol: 27, Pages: 1104-1109, ISSN: 0142-9612

Journal article

Owen CA, Selvakumaran J, Notingher I, Jell G, Hench LL, Stevens MMet al., 2006, In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy, JOURNAL OF CELLULAR BIOCHEMISTRY, Vol: 99, Pages: 178-186, ISSN: 0730-2312

Journal article

J George, M Shaffer, M Stevens, 2006, Investigating the cellular response to nanofibrous materials by use of a multi-walled carbon nanotube model, J Exp Nanoscience, Vol: 1, Pages: 1-12

Journal article

Stevens MM, Mayer M, Anderson DG, Weibel DB, Whitesides GM, Langer Ret al., 2005, Direct patterning of mammalian cells onto porous tissue engineering substrates using agarose stamps, Biomaterials, Vol: 26, Pages: 7636-7641, ISSN: 0142-9612

Journal article

Stevens MM, Marini RP, Schaefer D, Aronson J, Langer R, Shastri VPet al., 2005, In vivo engineering of organs: The bone bioreactor, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 11450-11455, ISSN: 0027-8424

Journal article

Notingher L, Jell G, Notingher PL, Bisson I, Tsigkou O, Polak JM, Stevens MM, Hench LLet al., 2005, Multivariate analysis of Raman spectra for in vitro non-invasive studies of living cells, 27th European Congress on Molecular Spectroscopy, Publisher: ELSEVIER SCIENCE BV, Pages: 179-185, ISSN: 0022-2860

Conference paper

Stevens MM, Allen S, Davies MC, Roberts CJ, Sakata JK, Tendler SJB, Tirrell DA, Williams PMet al., 2005, Molecular level investigations of the inter- and intramolecular interactions of pH-responsive artificial triblock proteins, BIOMACROMOLECULES, Vol: 6, Pages: 1266-1271, ISSN: 1525-7797

Journal article

Jell G, Bonzani I, Stevens M, 2005, Stem cells in regenerative medicine, Pharmaceutical Journal, Vol: 275, Pages: 695-698

Journal article

Stevens MM, Burdick JA, 2005, Biomedical hydrogels, Biomaterials, artificial organs and tissue engineering, Editors: Hench, Jones, Boca Raton, Publisher: Woodhead Publishing Limited, Pages: 107-115, ISBN: 9780849325779

Book chapter

Stevens MM, George JH, 2005, Exploring and engineering the cell surface interface, Science, Vol: 310, Pages: 1135-1138, ISSN: 0036-8075

Journal article

Prasad VP, Stevens MM, 2005, Polymer foams, Encyclopedia of biomaterials and biomedical engineering, Editors: Wnek, New York, Publisher: Dekker, Pages: 1274-1278, ISBN: 9780824755621

Book chapter

Stevens MM, Marini RP, Martin I, Langer R, Shastri VPet al., 2004, FGF-2 enhances TGF-beta 1-induced periosteal chondrogenesis, JOURNAL OF ORTHOPAEDIC RESEARCH, Vol: 22, Pages: 1114-1119, ISSN: 0736-0266

Journal article

Stevens MM, 2004, Periosteal stem cells in musculoskeletal tissue engineering, JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol: 56, Pages: S98-S98, ISSN: 0022-3573

Journal article

Tsigkou O, Boccaccini A, Hench LL, Polak JM, Stevens MMet al., 2004, Effect of PDLLA/Bioglass composite films on expression at the mRNA level of collagen type I and bone sialoprotein in fetal osteoblasts, JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol: 56, Pages: S36-S36, ISSN: 0022-3573

Journal article

Stevens MM, Allen S, Sakata JK, Davies MC, Roberts CJ, Tendler SJB, Tirrell DA, Williams PMet al., 2004, pH-Dependent behavior of surface-immobilized artificial leucine zipper proteins, LANGMUIR, Vol: 20, Pages: 7747-7752, ISSN: 0743-7463

Journal article

Marini RR, Stevens MM, Langer R, Shastri VPet al., 2004, Hydraulic elevation of the periosteum: A novel technique for periosteal harvest, JOURNAL OF INVESTIGATIVE SURGERY, Vol: 17, Pages: 229-233, ISSN: 0894-1939

Journal article

Stevens MM, Flynn NT, Wang C, Tirrell DA, Langer Ret al., 2004, Coiled-coil peptide-based assembly of gold nanoparticles, ADVANCED MATERIALS, Vol: 16, Pages: 915-918, ISSN: 0935-9648

Journal article

Xu XJ, Sy JC, Stevens MM, Shastri VPet al., 2004, Surface eroding polyesters derived from poly(alpha-hydroxy acids)., 227th National Meeting of the American-Chemical Society, Publisher: AMER CHEMICAL SOC, Pages: U558-U558, ISSN: 0065-7727

Conference paper

Stevens MM, Qanadilo HF, Langer R, Shastri VPet al., 2004, A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering, BIOMATERIALS, Vol: 25, Pages: 887-894, ISSN: 0142-9612

Journal article

Sy J, Xu X, Lipski AM, Stevens M, Shastri VPet al., 2004, Degradation behavior of novel poly(alpha-hydroxy acid)-derived polyesters, Pages: 199-206, ISSN: 0272-9172

Conference paper

Stevens MM, Langer RS, Marini RP, Martin I, Qanadilo HF, Shastri PVet al., 2003, Enhancement of periosteum derived chondrogenesis in vitro: Implications for cartilage tissue engineering, 49th annual meeting; Orthopaedic Research Society, New Orleans, LA, Publisher: ORS, Pages: 964-964, ISSN: 0149-6433

Conference paper

Stevens MM, Allen S, Davies MC, Roberts CJ, Schacht E, Tendler SJB, VanSteenkiste S, Williams PMet al., 2002, The development, characterization, and demonstration of a versatile immobilization strategy for biomolecular force measurements, LANGMUIR, Vol: 18, Pages: 6659-6665, ISSN: 0743-7463

Journal article

Stevens MM, Qanadilo HF, Langer R, Marini RP, Martin I, Shastri VPet al., 2002, Ionically crosslinked alginate hydrogels as scaffolds for periosteum-derived chondrogenesis, British pharmaceutical conference, Manchester, Publisher: Pharmaceutical press, Pages: 187-187, ISSN: 0022-3573

Conference paper

Williams PM, Moore A, Stevens MM, Allen S, Davies MC, Roberts CJ, Tendler SJBet al., 2001, On the dynamic behaviour of the forced dissociation of ligand-receptor pairs, Journal of the Chemical Society. Perkin Transactions 2, Pages: 5-8, ISSN: 0300-9580

Measurement of the forced rupture of biotin from streptavidin, using the force microscope, revealed a logarithmic dependence on the rate of loading. Transition state theory predicts that the rupture force is dependent on the rate of force loading and the dissociation rate constant of the interaction. Analysis of the dependence of the rupture force with loading rate reveals that the barrier to unbinding under the loading rates employed here is situated between 0.12 and 0.18 nm away from the bound state. The position of the barrier determined is similar in value to the results obtained using complementary force techniques, and is matched by calculations from computational simulation. Thus, force rupture measurements may be used to profile the internal energy pathway of molecular dissociation events. The results suggest, however, that the loading rates employed here, using cantilever retract velocities as low as 1 nm s-1, are still too high to explore the whole of the unbinding energy landscape, and suggests further avenues for instrumental and experimental development.

Journal article

Stevens MM, Allen S, Chan WC, Davies MC, Roberts CJ, Tendler SJ, Williams PMet al., 2000, Probing protein-peptide-protein molecular architecture by atomic force microscopy and surface plasmon resonance., Analyst, Vol: 125, Pages: 245-250, ISSN: 0003-2654

We demonstrate the creation of a protein multilayer which utilises the high affinity interaction between streptavidin and biotin and incorporates a peptidic spacer. Surface plasmon resonance measurements enabled us to monitor the construction of the multilayer in real time. Atomic force microscopy was utilised to determine surface functionality at each stage of the multilayer construction, allowing us to investigate the associated mechanical properties. In this context we observed an increase in biomolecular stretching on the formation of the multilayer. We demonstrate, utilising circular dichroism, that variations in the solvent can affect the secondary structure of the peptide linker and hence its mechanical properties. Trifluoroethanol titrations on the assembled system indicate that the multilayer properties are also stimuli responsive with regard to solvent conditions. These results indicate that the multilayer stretch before cleavage is increased in the presence of trifluoroethanol. This was not expected from the study of the individual linker alone, indicating the need to study the system as a whole as opposed to the isolated components.

Journal article

Williams PM, Moore A, Stevens MM, Allen S, Davies MC, Roberts CJ, Tendler SJBet al., 2000, On the dynamic behaviour of the forced dissociation of ligand-receptor pairs, Journal of the Chemical Society. Perkin Transactions 2, Pages: 5-8, ISSN: 0300-9580

Measurement of the forced rupture of biotin from streptavidin, using the force microscope, revealed a logarithmic dependence on the rate of loading. Transition state theory predicts that the rupture force is dependent on the rate of force loading and the dissociation rate constant of the interaction. Analysis of the dependence of the rupture force with loading rate reveals that the barrier to unbinding under the loading rates employed here is situated between 0.12 and 0.18 nm away from the bound state. The position of the barrier determined is similar in value to the results obtained using complementary force techniques, and is matched by calculations from computational simulation. Thus, force rupture measurements may be used to profile the internal energy pathway of molecular dissociation events. The results suggest, however, that the loading rates employed here, using cantilever retract velocities as low as 1 nm s-1, are still too high to explore the whole of the unbinding energy landscape, and suggests further avenues for instrumental and experimental development.

Journal article

Björnmalm M, Wong LM, Wojciechowski J, Penders J, Horgan C, Booth M, Martin N, Sattler S, Stevens Met al., In Vivo Biocompatibility and Immunogenicity of Metal-Phenolic Gelation, Publisher: American Chemical Society (ACS)

<jats:p>In vivo forming hydrogels are of interest for diverse biomedical applications due to their ease-of-use and minimal invasiveness and therefore high translational potential. Supramolecular hydrogels that can be assembled using metal–phenolic coordination of naturally occurring polyphenols and group IV metal ions (e.g. Ti&lt;sup&gt;IV &lt;/sup&gt;or Zr&lt;sup&gt;IV&lt;/sup&gt;) provide a versatile and robust platform for engineering such materials. However, the in situ formation and in vivo response to this new class of materials has not yet been reported. Here, we demonstrate that metal–phenolic supramolecular gelation occurs successfully in vivo and we investigate the host response to the material over 14 weeks. The Ti&lt;sup&gt;IV&lt;/sup&gt;–tannic acid materials form stable gels that are well-tolerated following subcutaneous injection. Histology reveals a mild foreign body reaction, and titanium biodistribution studies show low accumulation in distal tissues. Compared to poloxamer-based hydrogels (commonly used for in vivo gelation), Ti&lt;sup&gt;IV&lt;/sup&gt;–tannic acid materials show substantially improved in vitro drug loading and release profile for the corticosteroid dexamethasone (from &lt;1 day to &gt;10 days). These results provide essential in vivo characterization for this new class of metal–phenolic hydrogels, and highlight their potential suitability for biomedical applications in areas such as drug delivery and regenerative medicine.&lt;br&gt;</jats:p>

Working paper

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00398347&limit=30&person=true&page=12&respub-action=search.html