Imperial College London
Alternate

Professor MENGXING TANG

Faculty of Engineering, Department of Bioengineering

Professor of Biomedical Imaging
 
 
 
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Contact

 

+44 (0)20 7594 3664mengxing.tang Website

 
 
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Location

 

3.13Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2011:10.1364/OE.19.007299,
author = {Li, R and Elson, DS and Dunsby, C and Eckersley, R and Tang, MX},
doi = {10.1364/OE.19.007299},
journal = {Opt Express},
pages = {7299--7311},
title = {Effects of acoustic radiation force and shear waves for absorption and stiffness sensing in ultrasound modulated optical tomography.},
url = {http://dx.doi.org/10.1364/OE.19.007299},
volume = {19},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ultrasound-modulated optical tomography (UOT) combines optical contrast with ultrasound spatial resolution and has great potential for soft tissue functional imaging. One current problem with this technique is the weak optical modulation signal, primarily due to strong optical scattering in diffuse media and minimal acoustically induced modulation. The acoustic radiation force (ARF) can create large particle displacements in tissue and has been shown to be able to improve optical modulation signals. However, shear wave propagation induced by the ARF can be a significant source of nonlocal optical modulation which may reduce UOT spatial resolution and contrast. In this paper, the time evolution of shear waves was examined on tissue mimicking-phantoms exposed to 5 MHz ultrasound and 532 nm optical radiation and measured with a CCD camera. It has been demonstrated that by generating an ARF with an acoustic burst and adjusting both the timing and the exposure time of the CCD measurement, optical contrast and spatial resolution can be improved by ~110% and ~40% respectively when using the ARF rather than 5 MHz ultrasound alone. Furthermore, it has been demonstrated that this technique simultaneously detects both optical and mechanical contrast in the medium and the optical and mechanical contrast can be distinguished by adjusting the CCD exposure time.
AU  - Li,R
AU  - Elson,DS
AU  - Dunsby,C
AU  - Eckersley,R
AU  - Tang,MX
DO  - 10.1364/OE.19.007299
EP  - 7311
PY  - 2011///
SP  - 7299
TI  - Effects of acoustic radiation force and shear waves for absorption and stiffness sensing in ultrasound modulated optical tomography.
T2  - Opt Express
UR  - http://dx.doi.org/10.1364/OE.19.007299
UR  - http://www.ncbi.nlm.nih.gov/pubmed/21503041
UR  - http://hdl.handle.net/10044/1/9882
VL  - 19
ER  -
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