Summary
I am a consultant cardiologist and honorary lecturer. My interests are cardiac MRI, complex echo and cardiac CT.
My ongoing research projects involve using cardiac MRI to phenotype patients with hypertrophic cardiomyopathy (HCM) and also a large cohort of healthy volunteers, in order to perform phenotype-genotype association studies in association with Imperial College and the Cardiovascular Biomedical Research Unit (BRU) at the Royal Brompton Hospital.
Clinical supervisors:
Prof Stuart Cook
Dr Declan O''Regan
Collaborators:
Prof Justin Mason
Dr Antonio de Marvao
Dr Tim Dawes
Publications
de Marvao A, Dawes TJ, Shi W, Minas C, Keenan NG, Diamond T, Durighel G, Montana G, Rueckert D, Cook SA, O'Regan DP. Population-based studies of myocardial hypertrophy: high resolution cardiovascular magnetic resonance atlases improve statistical power. J Cardiovasc Magn Reson. 2014;16:16.
Keenan NG, Pugliese F, Davies L. The role of computed tomography in cardiovascular imaging: from X-ray department to emergency room. Expert Rev Cardiovasc Ther. 2014;12:57-69.
St Noble V, Keenan NG, Hillier J, Padley SP, Nicol ED. Interdisciplinary training in cardiovascular imaging in the UK - a novel, co-productive, synergistic approach. BMJ Careers 2013. http://careers.bmj.com/careers/advice/view-article.html?id=20013962
Corden B, Keenan NG, de Marvao AS, Dawes TJ, Decesare A, Diamond T, Durighel G, Hughes AD, Cook SA, O'Regan DP. Body fat is associated with reduced aortic stiffness until middle age. Hypertension. 2013;61:1322-7.
Keenan NG. BJCA trainee survey. Br J Cardiol 2013;20:8-9 [editorial]
Lane J, Keenan NG, Rogers D. Panhypopituitarism presenting as syncopal long QT. Lancet 2012;379:1922.
Gunawardana NP, Keenan NG, Moon JC, Rakhit R. Cardiac arrest and myocardial pseudoinfarction in sarcoidosis. Lancet 2012;379:1074.
Keenan NG, Brochet E, Juliard J-M, Malanca M, Aubry P, Lepage L, Cueff C, Jondeau G, Iung B, Vahanian A, Messika-Zeitoun D. Aortic Root Dilatation in Young Patients with Cryptogenic Stroke and Patent Foramen Ovale. Arch Cardiovasc Dis. 2012; 105:13-17
Cueff C, Keenan NG, Krapf L, Steg PG, Cimadevilla C, Ducrocq G, Michel JB, Vahanian A, Messika-Zeitoun D. Screening for abdominal aortic aneurysm in coronary care unit patients with acute myocardial infarction using portable transthoracic echocardiography. Eur Heart J Cardiovasc Imaging. 2012;13:574-8.
Pennell DJ, Keenan NG. Coronary Microvascular Dysfunction in Systemic Lupus Erythematosus Identified by CMR Imaging. JACC Cardiovasc Imaging. 2011;4:34-6. [Editorial]
Lekadir K, Keenan NG, Pennell DJ, Yang GZ. An inter-landmark approach to 4-D shape extraction and interpretation: application to myocardial motion assessment in MRI. IEEE Trans Med Imaging. 2011;30:52-68.
Keenan NG, Cueff C, Cimadevilla C, Brochet E, Iung B, Vahanian A, Messika-Zeitoun D. Usefulness of Left Atrial Volume versus Diameter to Assess Thromboembolic Risk in Mitral Stenosis. American Journal of Cardiology. 2010;106:1152-6.
Locca D, Bucciarelli-Ducci C, Ferrante G, La Manna A, Keenan NG, Grasso A, Barlis P, Del Furia F, Prasad SK, Kaski JC, Pennell DJ, Di Mario C. New universal definition of Myocardial infarction following Complex Percutaneous Coronary Interventions: a Cardiovascular Magnetic Resonance Study. 2010;3:950-8.
Keenan NG, Cueff C, Cimadevilla C, Brochet E, Raffoul R, Brochet E, Vahanian A, Messika-Zeitoun D. Diagnosis of early dysfunction of a tissue mitral valve replacement by three-dimensional transesophageal echocardiography. European Journal of Echocardiography. 2010;11:E33.
Keenan NG, Sheppard MN, Grasso A, Chan CF, Mukherjee RK, Boyle JJ, Gatehouse PD, Firmin DN, Pennell DJ. Validation of carotid arterial wall volume measurement by cardiovascular magnetic resonance. J Magn Reson Imaging. 2010; 31: 935-41.
Chan CF, Keenan NG, Nielles-Vallespin S, Gatehouse P, Sheppard MN, Boyle JJ, Pennell DJ, Firmin DN. Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque. J Cardiovasc Magn Reson. 2010; 12: 17.
Bradlow WM, Hughes ML, Keenan NG, Bucciarelli-Ducci C, Assomull R, Gibbs JS, Mohiaddin RH. Measuring the heart in pulmonary arterial hypertension (PAH): implications for trial study size. J Magn Reson Imaging. 2010; 31: 117-24.
Soloperto G, Keenan N, Sheppard MN, Wood N, Pennell DJ, Mohiaddin RH, Xu XY. Combined imaging, computational and histological analysis of a ruptured carotid plaque: a patient-specific analysis. Artery research 2010;4:59-65.
Keenan NG, Sheppard MN, Nott DM, Pennell DJ, Mohiaddin RH. Carotid Plaque Rupture. Lancet 2009;374:1703.
Keenan NG, Mason JC, Maceira A, Assomull R, O’Hanlon R, Chan C, Roughton M, Andrews J, Gatehouse PD, Firmin DN, Pennell DJ. Integrated Cardiac and Vascular Assessment in Takayasu’s Arteritis by Cardiovascular Magnetic Resonance. Arthritis and Rheumatism 2009; 60: 3501-3509.
Keenan NG, Locca D, Varghese D, Roughton M, Gatehouse PD, Hooper J, Firmin DN, Pennell DJ. Magnetic Resonance of Carotid Artery Ageing in Healthy Subjects. Atherosclerosis. 2009;205:168-73.
Varghese A, Yee MS, Chan CF, Crowe LA, Keenan NG, Johnston DG, Pennell DJ. Effect of rosiglitazone on progression of atherosclerosis – Insights using 3D carotid cardiovascular magnetic resonance. JCMR 2009;11:24.
Ball MJ, Keenan N, Lynch M, Prasad S, Gorog DA Identifying the aetiology of left ventricular hypertrophy in an athlete: importance of lifestyle modification. BMJ Case Reports 2009; doi:10.1136/bcr.10.2008.1080
Keenan NG, Grasso A, Locca D, Varghese A, Roughton M, Gatehouse PD, Firmin DN, Pennell DJ. Comparison of 2D and Multi-slab 3D Magnetic Resonance Techniques For Measuring Carotid Wall Volumes. J Magn Reson Imaging. 2008;28:1476-82.
Keenan NG, Nicholson A, Oldershaw PJ. Fatal Acute Pulmonary Hypertension Caused by Pulmonary Tumour Thrombotic Microangiopathy. Int J Cardiol. 2008; 124: e11-13.
Webb CM, Elkington AG, Kraidly MM, Keenan N, Pennell DJ, Collins P. Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease. Am J Cardiol 2008; 101: 618-624.
Keenan NG, Pennell DJ, Mohiaddin RH. Glagov Remodelling in the Atherosclerotic Carotid Artery by Cardiovascular Magnetic Resonance. Heart. 2008; 94: 228.
Keenan N, Pennell DJ. CMR of ventricular function. Echocardiography 2007; 24: 185-193. (Invited review).
Assomull RG, Lyne JC, Keenan N, Gulati A, Bunce NH, Davies SW, Pennell DJ, Prasad SK. The Role of Cardiovascular Magnetic Resonance in Patients Presenting with Chest Pain, Raised Troponin and Unobstructed Coronary Arteries. Eur Heart J 2007; 28: 1242-1249.
Lekadir K, Keenan N, Pennell D, Yang GZ. Shape-based myocardial contractility analysis using multivariate outlier detection. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2007; 10: 834-841.
Keenan N, Hatfield E, Barakat MT, Williams GR, Todd J. Pneumocystis pneumonia complicating a case of ectopic-ACTH derived Cushing’s Syndrome- only after cortisol-lowering therapy was initiated. Lancet 2006; 367: 446.
Keenan N, Davies S, Sheppard MN, Maceira A, Serino W, Mohiaddin RH. Angiosarcoma of the Right Atrium: a Diagnostic Dilemma. Int J Cardiol 2006; 113: 425-426.
Varghese A, Merrifield RD, Crowe LA, Collins SA, Keenan NG, Firmin DN, Yang GZ, Pennell DJ. Evaluation of carotid artery wall volume measurement using novel semiautomated analysis software. J Magn Reson Imaging 2006; 24: 1401-1408.
Keenan N, Jeyaratnam D, Sheerin NS. Mycobacterium simiae: a Previously Undescribed Pathogen in Peritoneal Dialysis Peritonitis. American Journal of Kidney Disease. 2005;45:e75-8.
Book ChapterS
Keenan NG, Nicol E. Cardiac Cardiovascular CT: Indications, Techniques, Perspectives. In: Recent Advances in Cardiology 16. Eds: Rowlands DJ, Clarke B. Royal Society of Medicine Press, London, UK. [In press]
Keenan NG, Pennell DJ. Cardiovascular magnetic resonance of the atheromatous plaque: achievements, anticipated developments, clinical application. In: Recent Advances in Cardiology 15. Eds: Rowlands DJ, Clarke B. Royal Society of Medicine Press, London, UK. 2008: 185-201.
Publications
Journals
Keenan NG, Captur G, McCann GP, et al., 2021, Regional variation in cardiovascular magnetic resonance service delivery across the UK, Heart, Vol:107, ISSN:1355-6037, Pages:1974-1979