Imperial College London
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ProfessorNeenaModi

Faculty of Medicine, School of Public Health

Vice-Dean (International Activities) Faculty of Medicine
 
 
 
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Contact

 

+44 (0)20 3315 5102n.modi Website

 
 
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Assistant

 

Miss Angela Rochester +44 (0)20 7594 0937

 
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Location

 

G4.2Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Burgess-Shannon:2024:10.1136/archdischild-2023-325712,
author = {Burgess-Shannon, J and Chehrazi, M and Lanoue, J and Modi, N and Uthaya, SN},
doi = {10.1136/archdischild-2023-325712},
journal = {Arch Dis Child Fetal Neonatal Ed},
title = {Outcomes following the adoption of standard parenteral nutrition in preterm infants: a whole-population non-concurrent control study.},
url = {http://dx.doi.org/10.1136/archdischild-2023-325712},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To evaluate the impact of a quality improvement project of the adoption of standard parenteral nutrition (SPN) in preterm infants. DESIGN: Retrospective, multicentre, whole-population, non-concurrent control study using data from the UK National Neonatal Research Database between 1 January 2014 and 31 December 2020. SETTING: Neonatal units in London UK organised by geographical network. PATIENTS: Preterm infants <31 weeks' gestation. INTERVENTIONS: Introduction of two SPN formulations previously tested in randomised controlled trials (NEON and SCAMP). SCAMP delivers a higher target macronutrient intake. MAIN OUTCOME MEASURES: The primary outcome was survival to discharge from neonatal care without major morbidities. Secondary outcomes included the individual components of the primary outcome and a comparison of outcomes between the NEON and the SCAMP formulations. RESULTS: Of 6538 eligible infants, 4693 were admitted to neonatal care before and 1845 after the adoption of SPN. Morbidity-free survival decreased by an average of 8.6% (95% CI 5.8% to 11.4%, p<0.0001) following adoption. The effect varied by type of formulation; the cohort that adopted NEON showed no difference in morbidity-free survival, whereas the cohort that adopted SCAMP showed a statistically significant decrease in morbidity-free survival. Overall survival decreased by an average of 2.0% (95% CI 0.01% to 4.0%, p=0.048). CONCLUSIONS: Research is urgently needed to identify the optimal composition of parenteral nutrition for preterm babies. This study also adds to the growing body of evidence that suggests that early and high intakes of macronutrients in preterm babies may be harmful.
AU  - Burgess-Shannon,J
AU  - Chehrazi,M
AU  - Lanoue,J
AU  - Modi,N
AU  - Uthaya,SN
DO  - 10.1136/archdischild-2023-325712
PY  - 2024///
TI  - Outcomes following the adoption of standard parenteral nutrition in preterm infants: a whole-population non-concurrent control study.
T2  - Arch Dis Child Fetal Neonatal Ed
UR  - http://dx.doi.org/10.1136/archdischild-2023-325712
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38442954
ER  -
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