ProfessorNadiaRosenthal

ROSENTHAL N, KRESS M, GRUSS P, KHOURY Get al., 1983, BK VIRAL ENHANCER ELEMENT AND A HUMAN CELLULAR HOMOLOG, SCIENCE, Vol: 222, Pages: 749-755, ISSN: 0036-8075

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• Citations: 146

Lomedico PT, Rosenthal N, Kolodner R, Efstratiadis A, Gilbert Wet al., 1980, The structure of rat preproinsulin genes., Ann N Y Acad Sci, Vol: 343, Pages: 425-432, ISSN: 0077-8923

In rat there are two nonallelic insulins, I and II. We have cloned and sequenced double stranded cDNA copies of both preproinsulin mRNA I and II. Using the cloned sequence as probe, we established by the Southern blotting technique a restriction map of the two chromosomal genes. This map indicates that an intron exists within the insulin II gene. To examine this in more detail, we have isolated both genes from a library of rat DNA cloned in phage lambda. Restriction endonuclease analysis and direct DNA sequencing revealed that gene II contains two introns: a 490 base pair intron between the region encoding amino acids 38 and 39 of proinsulin, and a 119 base pair intron, which is 17 base pairs upstream from the initiation codon. Gene I is not interrupted within the protein coding region, but possesses an intron homologous to the 119 base pair intron of insulin II. We are studying the structure of insulin genes from other species to determine if the 490 base pair intron was lost or inserted in the duplicated gene. We have identified nuclear RNA molecules larger than preproinsulin mRNA which contain the transcribed intronic sequences. These molecules represent a new precursor in insulin biosynthesis.

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LOMEDICO P, ROSENTHAL N, EFSTRATIADIS A, GILBERT W, KOLODNER R, TIZARD Ret al., 1979, STRUCTURE AND EVOLUTION OF THE 2 NONALLELIC RAT PREPROINSULIN GENES, CELL, Vol: 18, Pages: 545-558, ISSN: 0092-8674

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• Citations: 492

JONES CW, ROSENTHAL N, RODAKIS GC, KAFATOS FCet al., 1979, EVOLUTION OF 2 MAJOR CHORION MULTIGENE FAMILIES AS INFERRED FROM CLONED CDNA AND PROTEIN SEQUENCES, CELL, Vol: 18, Pages: 1317-1332, ISSN: 0092-8674

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• Citations: 85

HARDISON RC, BUTLER ET, LACY E, MANIATIS Tet al., 1979, STRUCTURE AND TRANSCRIPTION OF 4 LINKED RABBIT BETA-LIKE GLOBIN GENES, CELL, Vol: 18, Pages: 1285-1297, ISSN: 0092-8674

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• Citations: 165

Sim GK, Efstratiadis A, Jones CW, Kafatos FC, Koehler M, Kronenberg HM, Maniatis T, Regier JC, Roberts BF, Rosenthal Net al., 1978, Studies on the structure of genes expressed during development., Cold Spring Harb Symp Quant Biol, Vol: 42 Pt 2, Pages: 933-945, ISSN: 0091-7451

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SIM GK, EFSTRATIADIS A, JONES CW, KAFATOS FC, KOEHLER M, KRONENBERG HM, MANIATIS T, REGIER JC, ROBERTS BF, ROSENTHAL Net al., 1977, STUDIES ON STRUCTURE OF GENES EXPRESSED DURING DEVELOPMENT, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, Vol: 42, Pages: 933-945, ISSN: 0091-7451

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• Citations: 12

Rosenthal N, Harvey RP, Palmer S, Musaro Aet al., Novel molecules expressed during muscle development and genetic sequences encoding the same, pending

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Rosenthal N, Musaro A, Winn N, IGF-1 novel peptides, UK pending

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Sweeney L, Rosenthal N, The use of insulin-like growth factor-1 in muscle, 6,723,707

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