Imperial College London
Alternate

ProfessorNadiaRosenthal

Faculty of Medicine, National Heart & Lung Institute

Chair in Cardiovascular Science&ScientificDirector
 
 
 
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Contact

 

+44 (0)20 7594 2737n.rosenthal

 
 
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Location

 

424W2ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kratsios:2010:10.1161/CIRCRESAHA.109.203034,
author = {Kratsios, P and Catela, C and Salimova, E and Huth, M and Berno, V and Rosenthal, N and Mourkioti, F},
doi = {10.1161/CIRCRESAHA.109.203034},
journal = {CIRCULATION RESEARCH},
pages = {559--572},
title = {Distinct Roles for Cell-Autonomous Notch Signaling in Cardiomyocytes of the Embryonic and Adult Heart},
url = {http://dx.doi.org/10.1161/CIRCRESAHA.109.203034},
volume = {106},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale: The Notch signaling pathway is important for cell-cell communication that controls tissue formation and homeostasis during embryonic and adult life, but the precise cell targets of Notch signaling in the mammalian heart remain poorly defined.Objective: To investigate the functional role of Notch signaling in the cardiomyocyte compartment of the embryonic and adult heart.Methods and Results: Here, we report that either conditional overexpression of Notch1 intracellular domain (NICD1) or selective silencing of Notch signaling in the embryonic cardiomyocyte compartment results in developmental defects and perinatal lethality. In contrast, augmentation of endogenous Notch reactivation after myocardial infarction in the adult, either by inducing cardiomyocyte-specific Notch1 transgene expression or by intramyocardial delivery of a Notch1 pseudoligand, increases survival rate, improves cardiac functional performance, and minimizes fibrosis, promoting antiapoptotic and angiogenic mechanisms.Conclusions: These results reveal a strict requirement for cell-autonomous modulation of Notch signaling during heart morphogenesis, and illustrate how the same signaling pathway that promotes congenital heart defects when perturbed in the embryo can be therapeutically redeployed for the treatment of adult myocardial damage. (Circ Res. 2010;106:559-572.)
AU  - Kratsios,P
AU  - Catela,C
AU  - Salimova,E
AU  - Huth,M
AU  - Berno,V
AU  - Rosenthal,N
AU  - Mourkioti,F
DO  - 10.1161/CIRCRESAHA.109.203034
EP  - 572
PY  - 2010///
SN  - 0009-7330
SP  - 559
TI  - Distinct Roles for Cell-Autonomous Notch Signaling in Cardiomyocytes of the Embryonic and Adult Heart
T2  - CIRCULATION RESEARCH
UR  - http://dx.doi.org/10.1161/CIRCRESAHA.109.203034
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000274651400019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 106
ER  -
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