Imperial College London
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ProfessorNagyHabib

Faculty of Medicine, Department of Surgery & Cancer

Professor of Hepatobiliary Surgery
 
 
 
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Contact

 

+44 (0)20 3313 8574nagy.habib

 
 
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Assistant

 

Mrs Benita White +44 (0)7960 986 387

 
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Location

 

BN1/18 B BlockHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kallis:2015:10.1007/s10620-015-3731-8,
author = {Kallis, Y and Phillips, N and Steel, A and Kaltsidis, H and Vlavianos, P and Habib, N and Westaby, D},
doi = {10.1007/s10620-015-3731-8},
journal = {Digestive Diseases and Sciences},
pages = {3449--3455},
title = {Analysis of endoscopic radiofrequency ablation of biliary malignant strictures in pancreatic cancer suggests potential survival benefit},
url = {http://dx.doi.org/10.1007/s10620-015-3731-8},
volume = {60},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPancreatic carcinoma is often inoperable, carries a poor prognosis, and is commonly complicated by malignant biliary obstruction. Phase I/II studies have demonstrated good safety and early stent patency using endoscopic biliary radiofrequency ablation (RFA) as an adjunct to self-expanding metal stent (SEMS) insertion for biliary decompression.AimTo analyze the clinical efficacy of endobiliary RFA.MethodsRetrospective case–control analysis was carried out for 23 patients with surgically unresectable pancreatic carcinoma and malignant biliary obstruction undergoing endoscopic RFA and SEMS insertion and 46 controls (SEMS insertion alone) in a single tertiary care center. Controls were stringently matched for age, sex, metastases, ASA/comorbidities. Survival, morbidity, and stent patency rates were assessed.ResultsRFA and control groups were closely matched—ASA 2.35 ± 0.65 versus 2.54 ± 0.50, p = 0.086; metastases 9/23 (39.1 %) versus 18/46 (39.1 %), p = 0.800; chemotherapy 16/23 (69.6 %) versus 24/46 (52.2 %), p = 0.203. Median survival in RFA group was 226 days (IQR 140–526 days) versus 123.5 days (IQR 44–328 days) in controls (p = 0.010). RFA was independently predictive of survival at 90 days (OR 21.07, 95 % CI 1.45–306.64, p = 0.026) and 180 days (OR 4.48, 95 % CI 1.04–19.30, p = 0.044) in multivariate analysis. SEMS patency rates were equivalent in both groups. RFA was well tolerated with minimal side effects.ConclusionsEndoscopic RFA is a safe and efficacious adjunctive treatment in patients with advanced pancreatic malignancy and biliary obstruction and may confer early survival benefit. Randomized prospective clinical trials of this new modality are mandated.
AU  - Kallis,Y
AU  - Phillips,N
AU  - Steel,A
AU  - Kaltsidis,H
AU  - Vlavianos,P
AU  - Habib,N
AU  - Westaby,D
DO  - 10.1007/s10620-015-3731-8
EP  - 3455
PY  - 2015///
SN  - 1573-2568
SP  - 3449
TI  - Analysis of endoscopic radiofrequency ablation of biliary malignant strictures in pancreatic cancer suggests potential survival benefit
T2  - Digestive Diseases and Sciences
UR  - http://dx.doi.org/10.1007/s10620-015-3731-8
UR  - http://hdl.handle.net/10044/1/33208
VL  - 60
ER  -
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