Imperial College London
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ProfessorPeterLee

Faculty of Engineering, Department of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6801p.d.lee

 
 
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Location

 

102Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chen:2019:10.1016/j.msec.2018.10.033,
author = {Chen, Y and Han, P and Vandi, L-J and Dehghan-Manshadi, A and Humphry, J and Kent, D and Stefani, I and Lee, P and Heitzmann, M and Cooper-White, J and Darguscha, M},
doi = {10.1016/j.msec.2018.10.033},
journal = {Materials Science and Engineering: C},
pages = {160--165},
title = {A biocompatible thermoset polymer binder for Direct Ink Writing of porous titanium scaffolds for bone tissue engineering},
url = {http://dx.doi.org/10.1016/j.msec.2018.10.033},
volume = {95},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is increasing demand for synthetic bone scaffolds for bone tissue engineering as they can counter issues such as potential harvesting morbidity and restrictions in donor sites which hamper autologous bone grafts and address the potential for disease transmission in the case of allografts. Due to their excellent biocompatibility, titanium scaffolds have great potential as bone graft substitutes as they mimic the structure and properties of human cancellous bone. Here we report on a new thermoset bio-polymer which can act as a binder for Direct Ink Writing (DIW) of titanium artificial bone scaffolds. We demonstrate the use of the binder to manufacture porous titanium scaffolds with evenly distributed and highly interconnected porosity ideal for orthopaedic applications. Due to their porous structure, the scaffolds exhibit an effective Young's modulus similar to human cortical bone, alleviating undesirable stress-shielding effects, and possess superior strength. The biocompatibility of the scaffolds was investigated in vitro by cell viability and proliferation assays using human bone-marrow-derived Mesenchymal stem cells (hMSCs). The hMSCs displayed well-spread morphologies, well-organized F-actin and large vinculin complexes confirming their excellent biocompatibility. The vinculin regions had significantly larger Focal Adhesion (FA) area and equivalent FA numbers compared to that of tissue culture plate controls, showing that the scaffolds support cell viability and promote attachment. In conclusion, we have demonstrated the excellent potential of the thermoset bio-polymer as a Direct Ink Writing ready binder for manufacture of porous titanium scaffolds for hard tissue engineering.
AU  - Chen,Y
AU  - Han,P
AU  - Vandi,L-J
AU  - Dehghan-Manshadi,A
AU  - Humphry,J
AU  - Kent,D
AU  - Stefani,I
AU  - Lee,P
AU  - Heitzmann,M
AU  - Cooper-White,J
AU  - Darguscha,M
DO  - 10.1016/j.msec.2018.10.033
EP  - 165
PY  - 2019///
SN  - 1873-0191
SP  - 160
TI  - A biocompatible thermoset polymer binder for Direct Ink Writing of porous titanium scaffolds for bone tissue engineering
T2  - Materials Science and Engineering: C
UR  - http://dx.doi.org/10.1016/j.msec.2018.10.033
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000455858300018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69885
VL  - 95
ER  -
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