Imperial College London
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ProfessorPeterKohl

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.kohl Website

 
 
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Location

 

Heart Science CentreHarefield Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Garny:2003:10.1046/j.1540.8167.90301.x,
author = {Garny, A and Kohl, P and Hunter, PJ and Boyett, MR and Noble, D},
doi = {10.1046/j.1540.8167.90301.x},
journal = {J Cardiovasc Electrophysiol},
pages = {S121--S132},
title = {One-dimensional rabbit sinoatrial node models: benefits and limitations.},
url = {http://dx.doi.org/10.1046/j.1540.8167.90301.x},
volume = {14},
year = {2003}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Cardiac multicellular modeling has traditionally focused on ventricular electromechanics. More recently, models of the atria have started to emerge, and there is much interest in addressing sinoatrial node structure and function. METHODS AND RESULTS: We implemented a variety of one-dimensional sinoatrial models consisting of descriptions of central, transitional, and peripheral sinoatrial node cells, as well as rabbit or human atrial cells. These one-dimensional models were implemented using CMISS on an SGI Origin 2000 supercomputer. Intercellular coupling parameters recorded in experimental studies on sinoatrial node and atrial cell-pairs under-represent the electrotonic interactions that any cardiomyocyte would have in a multidimensional setting. Unsurprisingly, cell-to-cell coupling had to be scaled-up (by a factor of 5) in order to obtain a stable leading pacemaker site in the sinoatrial node center. Further critical parameters include the gradual increase in intercellular coupling from sinoatrial node center to periphery, and the presence of electrotonic interaction with atrial cells. Interestingly, the electrotonic effect of the atrium on sinoatrial node periphery is best described as opposing depolarization, rather than necessarily hyperpolarizing, as often assumed. CONCLUSION: Multicellular one-dimensional models of sinoatrial node and atrium can provide useful insight into the origin and spread of normal cardiac excitation. They require larger than "physiologic" intercellular conductivities in order to make up for a lack of "anatomical" spatial scaling. Multicellular models for more in-depth quantitative studies will require more realistic anatomico-physiologic properties.
AU  - Garny,A
AU  - Kohl,P
AU  - Hunter,PJ
AU  - Boyett,MR
AU  - Noble,D
DO  - 10.1046/j.1540.8167.90301.x
EP  - 132
PY  - 2003///
SN  - 1045-3873
SP  - 121
TI  - One-dimensional rabbit sinoatrial node models: benefits and limitations.
T2  - J Cardiovasc Electrophysiol
UR  - http://dx.doi.org/10.1046/j.1540.8167.90301.x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/14760914
VL  - 14
ER  -
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