Publications
230 results found
LANGFORD PR, MOXON ER, 1993, THE DILUTION RATE AFFECTS THE OUTER-MEMBRANE PROTEIN AND LIPOPOLYSACCHARIDE COMPOSITION OF HAEMOPHILUS-INFLUENZAE TYPE-B GROWN UNDER IRON LIMITATION, JOURNAL OF BACTERIOLOGY, Vol: 175, Pages: 2462-2464, ISSN: 0021-9193
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- Citations: 6
HOLLAND J, LANGFORD PR, TOWNER KJ, et al., 1992, EVIDENCE FOR INVIVO EXPRESSION OF TRANSFERRIN-BINDING PROTEINS IN HAEMOPHILUS-INFLUENZAE TYPE-B, INFECTION AND IMMUNITY, Vol: 60, Pages: 2986-2991, ISSN: 0019-9567
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- Citations: 35
Langford PR, Moxon ER, 1992, Growth of Haemophilus influenzae type b in continuous culture: effect of dilution rate on outer-membrane protein and lipopolysaccharide expression., FEMS Microbiol Lett, Vol: 72, Pages: 43-47, ISSN: 0378-1097
Haemophilus influenzae type b (Hib) was grown in continuous culture under cystine-limitation between dilution rates (D) of 0.065-0.28 h-1. A similar outer-membrane protein profile, as adjudged by SDS-PAGE, was found at all dilution rates. However, a shift to a lipopolysaccharide structure with a greater electrophoretic mobility on SDS-PAGE with accompanying changes in monoclonal antibody reactivity was observed at D greater than or equal to 0.15 h-1. Growth rate per se can affect the expression of outer-membrane components of Hib.
LANGFORD PR, MOXON ER, 1992, GROWTH OF HAEMOPHILUS-INFLUENZAE TYPE-B IN CONTINUOUS CULTURE - EFFECT OF DILUTION RATE ON OUTER-MEMBRANE PROTEIN AND LIPOPOLYSACCHARIDE EXPRESSION, FEMS MICROBIOLOGY LETTERS, Vol: 93, Pages: 43-47, ISSN: 0378-1097
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- Citations: 8
KROLL JS, LOYNDS BM, LANGFORD PR, 1992, PALINDROMIC HAEMOPHILUS DNA UPTAKE SEQUENCES IN PRESUMED TRANSCRIPTIONAL TERMINATORS FROM HAEMOPHILUS-INFLUENZAE AND HAEMOPHILUS-PARAINFLUENZAE, GENE, Vol: 114, Pages: 151-152, ISSN: 0378-1119
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- Citations: 10
LANGFORD PR, LOYNDS BM, KROLL JS, 1992, COPPER-ZINC SUPEROXIDE-DISMUTASE IN HAEMOPHILUS SPECIES, JOURNAL OF GENERAL MICROBIOLOGY, Vol: 138, Pages: 517-522, ISSN: 0022-1287
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- Citations: 36
LOYNDS BM, LANGFORD PR, KROLL JS, 1992, RECF IN ACTINOBACILLUS-PLEUROPNEUMONIAE, NUCLEIC ACIDS RESEARCH, Vol: 20, Pages: 615-615, ISSN: 0305-1048
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- Citations: 9
LANGFORD PR, WILLIAMS AE, MOXON ER, 1992, IMMUNOGENIC OUTER-MEMBRANE PROTEINS OF HAEMOPHILUS-INFLUENZAE TYPE-B IN INFECTION, JOURNAL OF GENERAL MICROBIOLOGY, Vol: 138, Pages: 155-159, ISSN: 0022-1287
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- Citations: 2
KROLL JS, LANGFORD PR, LOYNDS BM, 1991, COPPER-ZINC SUPEROXIDE-DISMUTASE OF HAEMOPHILUS-INFLUENZAE AND HAEMOPHILUS-PARAINFLUENZAE, JOURNAL OF BACTERIOLOGY, Vol: 173, Pages: 7449-7457, ISSN: 0021-9193
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- Citations: 99
LANGFORD PR, MOXON ER, 1991, GROWTH OF HAEMOPHILUS-INFLUENZAE TYPE B IN THE PRESENCE OF BOVINE AORTIC ENDOTHELIAL-CELLS, JOURNAL OF GENERAL MICROBIOLOGY, Vol: 137, Pages: 1577-1581, ISSN: 0022-1287
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- Citations: 2
Langford P, 1991, In vitro cytotoxicity of Haemophilus influenzae lipopolysaccharides for bovine aortal endothelial cells, FEMS Microbiology Letters, Vol: 81, Pages: 161-164, ISSN: 0378-1097
Langford PR, Szabo M, Moxon ER, 1991, In vitro cytotoxicity of Haemophilus influenzae lipopolysaccharides for bovine aortal endothelial cells., FEMS Microbiol Lett, Vol: 65, Pages: 161-164, ISSN: 0378-1097
The cytotoxicity of purified lipopolysaccharide (LPS) from a prototype Haemophilus influenzae type b (Hib) strain (Eagan) and three transformants, differing in their LPS phenotype, for bovine aortal endothelial cells (BAOEC) was investigated. All LPS preparations caused cell disruption and release of lactate dehydrogenase (LDH), an indicator of cytotoxicity, from BAOEC monolayers but to differing extents. There was no correlation between the cytotoxicity of purified Hib LPS to BAOEC monolayers and potential to cause bacteraemia in experimental animals.
LANGFORD PR, SZABO M, MOXON ER, 1991, INVITRO CYTOTOXICITY OF HAEMOPHILUS-INFLUENZAE LIPOPOLYSACCHARIDES FOR BOVINE AORTIC ENDOTHELIAL-CELLS, FEMS MICROBIOLOGY LETTERS, Vol: 81, Pages: 161-164, ISSN: 0378-1097
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- Citations: 4
LANGFORD P, WILLIAMS AE, KROLL JS, 1991, SUPEROXIDE DISMUTASES OF PATHOGENIC AND NONPATHOGENIC STREPTOCOCCUS-SUIS TYPE-2 ISOLATES, FEMS MICROBIOLOGY LETTERS, Vol: 77, Pages: 347-350, ISSN: 0378-1097
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- Citations: 21
Langford P, 1991, Superoxide dismutases of pathogenic and non-pathogenic Streptococcus suis type 2 isolates, FEMS Microbiology Letters, Vol: 77, Pages: 347-350, ISSN: 0378-1097
Langford PR, Anwar H, Gonda I, et al., 1989, Outer membrane proteins of gentamicin induced small colony variants of Pseudomonas aeruginosa., FEMS Microbiol Lett, Vol: 52, Pages: 33-36, ISSN: 0378-1097
Small colony variants (SCVs) of Pseudomonas aeruginosa NCTC 6750 (WT) were repeatedly isolated in an in vitro kinetic model after exposure to gentamicin (GM). There were minor differences biochemically and in phage and serotyping between the wild type (WT) strain and SCVs. Changes in outer membrane protein profiles were found. SCVs were more resistant to polymixin and to a range of aminoglycosides (except kanamycin), but were more susceptible to a range of other antibiotics (hydrophilic and hydrophobic) with differing modes of action.
LANGFORD PR, ANWAR H, GONDA I, et al., 1989, OUTER-MEMBRANE PROTEINS OF GENTAMICIN INDUCED SMALL COLONY VARIANTS OF PSEUDOMONAS-AERUGINOSA, FEMS MICROBIOLOGY LETTERS, Vol: 61, Pages: 33-36, ISSN: 0378-1097
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- Citations: 9
LANGFORD PR, HARPUR ES, GONDA I, et al., 1984, AN INVITRO MODEL OF NEPHROTOXICITY OF AMINOGLYCOSIDE ANTIBIOTICS, Publisher: STOCKTON PRESS LTD, Pages: 453-453, ISSN: 0144-5952
LANGFORD PR, HARPUR ES, KAYES JB, et al., 1982, STUDIES OF A POTENTIAL INVITRO TEST FOR ESTIMATION OF TOXICITY OF AMINOGLYCOSIDE ANTIBIOTICS AND POLYAMINES, JOURNAL OF ANTIBIOTICS, Vol: 35, Pages: 1387-1393, ISSN: 0021-8820
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- Citations: 13
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