Imperial College London
Alternate

Emeritus ProfessorPetrosNihoyannopoulos

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 3313 8156p.nihoyannopoulos

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Toutouzas:2017:10.1016/j.hjc.2017.02.002,
author = {Toutouzas, K and Klettas, D and Anousakis-Vlachochristou, N and Melidis, K and Azilazian, Z and Asimomiti, M and Karanasos, A and Spanos, A and Tsiamis, E and Nihoyannopoulos, P and Tousoulis, D},
doi = {10.1016/j.hjc.2017.02.002},
journal = {Hellenic J Cardiol},
pages = {80--86},
title = {The -174 G>C Interleukin-6 Gene Polymorphism is Associated with Angiographic Progression of Coronary Artery Disease over a 4-Year Period.},
url = {http://dx.doi.org/10.1016/j.hjc.2017.02.002},
volume = {58},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Inflammation is a key process underlying the clinical course of coronary artery disease (CAD). C-reactive protein (CRP) and interleukin-6 (IL-6) contribute to its pathophysiology and act as biomarkers. We sought to examine whether known single nucleotide polymorphisms (SNPs) impact CAD progression, reflecting increased inflammation. METHODS: We retrospectively evaluated coronary angiographies of patients with established CAD who were re-investigated for stable/unstable angina after a time interval of >12 months. We defined progression of CAD as the emergence of a new plaque or a ≥20 % increase of a formerly non-significant lesion. We genotyped patients for the 1846 C>T CRP and -174 G>C IL-6 SNPs. The probability of CAD progression among the Mendelian randomization groups was evaluated using the Kaplan-Meier method. Data were analyzed using a Cox model that included relevant clinical factors. RESULTS: A total of 157 patients were included. The serum levels of CRP and IL-6 differed significantly between genotypes. The genotype frequencies of IL-6 were consistent with Hardy-Weinberg equilibrium, whereas those for CRP were excluded from our conclusions. At 48 months, 83 patients (52.9 %) with the IL-6 C allele versus 74 (47.1 %) with the G allele exhibited CAD progression. Patients with the IL-6 C allele had a 52.8 % probability for progression versus 13.3 % for those with the G allele (p=0.005). The results were confirmed by multivariate analysis; dyslipidemia, family history, and IL-6 SNP emerged as significant factors. CONCLUSION: Patients with established CAD who carried the -174 C allele of the IL-6 gene demonstrated an increased risk for the progression of coronary plaques over a four-year period. Further studies will be needed to validate these findings.
AU  - Toutouzas,K
AU  - Klettas,D
AU  - Anousakis-Vlachochristou,N
AU  - Melidis,K
AU  - Azilazian,Z
AU  - Asimomiti,M
AU  - Karanasos,A
AU  - Spanos,A
AU  - Tsiamis,E
AU  - Nihoyannopoulos,P
AU  - Tousoulis,D
DO  - 10.1016/j.hjc.2017.02.002
EP  - 86
PY  - 2017///
SP  - 80
TI  - The -174 G>C Interleukin-6 Gene Polymorphism is Associated with Angiographic Progression of Coronary Artery Disease over a 4-Year Period.
T2  - Hellenic J Cardiol
UR  - http://dx.doi.org/10.1016/j.hjc.2017.02.002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28212870
VL  - 58
ER  -
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