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@article{Geretti:2020:cid/ciaa1605,
author = {Geretti, AM and Stockdale, AJ and Kelly, SH and Cevik, M and Collins, S and Waters, L and Villa, G and Docherty, A and Harrison, EM and Turtle, L and Openshaw, PJM and Baillie, JK and Sabin, CA and Semple, MG},
doi = {cid/ciaa1605},
journal = {Clinical Infectious Diseases},
pages = {e2095--e2106},
title = {Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.},
url = {http://dx.doi.org/10.1093/cid/ciaa1605},
volume = {73},
year = {2020}
}

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TY  - JOUR
AB  - BACKGROUND: Evidence is conflicting about how HIV modulates COVID-19. We compared the presentation characteristics and outcomes of adults with and without HIV who were hospitalized with COVID-19 at 207 centers across the United Kingdom and whose data were prospectively captured by the ISARIC WHO CCP study. METHODS: We used Kaplan-Meier methods and Cox regression to describe the association between HIV status and day-28 mortality, after separate adjustment for sex, ethnicity, age, hospital acquisition of COVID-19 (definite hospital acquisition excluded), presentation date, ten individual comorbidities, and disease severity at presentation (as defined by hypoxia or oxygen therapy). RESULTS: Among 47,592 patients, 122 (0.26%) had confirmed HIV infection and 112/122 (91.8%) had a record of antiretroviral therapy. At presentation, HIV-positive people were younger (median 56 versus 74 years; p<0.001) and had fewer comorbidities, more systemic symptoms and higher lymphocyte counts and C-reactive protein levels. The cumulative day-28 mortality was similar in the HIV-positive vs. HIV-negative groups (26.7% vs. 32.1%; p=0.16), but in those under 60 years of age HIV-positive status was associated with increased mortality (21.3% vs. 9.6%; p<0.001 [log-rank test]). Mortality was higher among people with HIV after adjusting for age (adjusted hazard ratio [aHR] 1.47, 95% confidence interval [CI] 1.01-2.14; p=0.05), and the association persisted after adjusting for the other variables (aHR 1.69; 95% CI 1.15-2.48; p=0.008) and when restricting the analysis to people aged <60 years (aHR 2.87; 95% CI 1.70-4.84; p<0.001). CONCLUSIONS: HIV-positive status was associated with an increased risk of day-28 mortality among patients hospitalized for COVID-19.
AU  - Geretti,AM
AU  - Stockdale,AJ
AU  - Kelly,SH
AU  - Cevik,M
AU  - Collins,S
AU  - Waters,L
AU  - Villa,G
AU  - Docherty,A
AU  - Harrison,EM
AU  - Turtle,L
AU  - Openshaw,PJM
AU  - Baillie,JK
AU  - Sabin,CA
AU  - Semple,MG
DO  - cid/ciaa1605
EP  - 2106
PY  - 2020///
SN  - 1058-4838
SP  - 2095
TI  - Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/ciaa1605
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33095853
UR  - https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1605/5937133
UR  - http://hdl.handle.net/10044/1/84592
VL  - 73
ER  -

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