Imperial College London
Alternate

ProfessorPaoloVineis

Faculty of Medicine, School of Public Health

Chair in Environmental Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3372p.vineis Website

 
 
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Location

 

511Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Van:2018:10.1186/s13059-017-1374-0,
author = {Van, Baak TE and Coarfa, C and Dugue, P-A and Fiorito, G and Laritsky, E and Baker, MS and Kessler, NJ and Dong, J and Duryea, JD and Silver, MJ and Saffari, A and Prentice, AM and Moore, SE and Ghantous, A and Routledge, MN and Gong, YY and Herceg, Z and Vineis, P and Severi, G and Hopper, JL and Southey, MC and Giles, GG and Milne, RL and Waterland, RA},
doi = {10.1186/s13059-017-1374-0},
journal = {Genome Biology},
title = {Epigenetic supersimilarity of monozygotic twin pairs},
url = {http://dx.doi.org/10.1186/s13059-017-1374-0},
volume = {19},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundMonozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of monozygotic twins have been assumed to be largely due to their genetic identity.ResultsHere, by analyzing data from a genome-scale study of DNA methylation in monozygotic and dizygotic twins, we identified genomic regions at which the epigenetic similarity of monozygotic twins is substantially greater than can be explained by their genetic identity. This “epigenetic supersimilarity” apparently results from locus-specific establishment of epigenotype prior to embryo cleavage during twinning. Epigenetically supersimilar loci exhibit systemic interindividual epigenetic variation and plasticity to periconceptional environment and are enriched in sub-telomeric regions. In case-control studies nested in a prospective cohort, blood DNA methylation at these loci years before diagnosis is associated with risk of developing several types of cancer.ConclusionsThese results establish a link between early embryonic epigenetic development and adult disease. More broadly, epigenetic supersimilarity is a previously unrecognized phenomenon that may contribute to the phenotypic similarity of monozygotic twins.
AU  - Van,Baak TE
AU  - Coarfa,C
AU  - Dugue,P-A
AU  - Fiorito,G
AU  - Laritsky,E
AU  - Baker,MS
AU  - Kessler,NJ
AU  - Dong,J
AU  - Duryea,JD
AU  - Silver,MJ
AU  - Saffari,A
AU  - Prentice,AM
AU  - Moore,SE
AU  - Ghantous,A
AU  - Routledge,MN
AU  - Gong,YY
AU  - Herceg,Z
AU  - Vineis,P
AU  - Severi,G
AU  - Hopper,JL
AU  - Southey,MC
AU  - Giles,GG
AU  - Milne,RL
AU  - Waterland,RA
DO  - 10.1186/s13059-017-1374-0
PY  - 2018///
SN  - 1474-7596
TI  - Epigenetic supersimilarity of monozygotic twin pairs
T2  - Genome Biology
UR  - http://dx.doi.org/10.1186/s13059-017-1374-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000419920500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60776
VL  - 19
ER  -
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