Imperial College London
Alternate

Dr Paras Anand

Faculty of Medicine, Department of Infectious Disease

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2063paras.anand Website

 
 
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Location

 

8.N23Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Anand:2020:10.1111/imr.12891,
author = {Anand, P},
doi = {10.1111/imr.12891},
journal = {Immunological Reviews},
pages = {108--122},
title = {Lipids, inflammasomes, metabolism and disease},
url = {http://dx.doi.org/10.1111/imr.12891},
volume = {297},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Inflammasomes are multiprotein complexes that regulate the cleavage of cysteine protease caspase1, secretion of inflammatory cytokines, and induction of inflammatory cell death, pyroptosis. Several members of the nodlike receptor family assemble inflammasome in response to specific ligands. An exception to this is the NLRP3 inflammasome which is activated by structurally diverse entities. Recent studies have suggested that NLRP3 might be a sensor of cellular homeostasis, and any perturbation in distinct metabolic pathways results in the activation of this inflammasome. Lipid metabolism is exceedingly important in maintaining cellular homeostasis, and it is recognized that cells and tissues undergo extensive lipid remodeling during activation and disease. Some lipids are involved in instigating chronic inflammatory diseases, and new studies have highlighted critical upstream roles for lipids, particularly cholesterol, in regulating inflammasome activation implying key functions for inflammasomes in diseases with defective lipid metabolism. The focus of this review is to highlight how lipids regulate inflammasome activation and how this leads to the progression of inflammatory diseases. The key roles of cholesterol metabolism in the activation of inflammasomes have been comprehensively discussed. Besides, the roles of oxysterols, fatty acids, phospholipids, and lipid second messengers are also summarized in the context of inflammasomes. The overriding theme is that lipid metabolism has numerous but complex functions in inflammasome activation. A detailed understanding of this area will help us develop therapeutic interventions for diseases where dysregulated lipid metabolism is the underlying cause.
AU  - Anand,P
DO  - 10.1111/imr.12891
EP  - 122
PY  - 2020///
SN  - 0105-2896
SP  - 108
TI  - Lipids, inflammasomes, metabolism and disease
T2  - Immunological Reviews
UR  - http://dx.doi.org/10.1111/imr.12891
UR  - http://hdl.handle.net/10044/1/80735
VL  - 297
ER  -
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