Imperial College London
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Professor Paul Edison

Faculty of Medicine, Department of Brain Sciences

Professor of Neuroscience
 
 
 
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Contact

 

paul.edison

 
 
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Location

 

2S 5A, Level 2Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Edison:2024:10.1002/alz.13678,
author = {Edison, P},
doi = {10.1002/alz.13678},
journal = {Alzheimers Dement},
title = {Astroglial activation: Current concepts and future directions.},
url = {http://dx.doi.org/10.1002/alz.13678},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Astrocytes are abundantly and ubiquitously expressed cell types with diverse functions throughout the central nervous system. Astrocytes show remarkable plasticity and exhibit morphological, molecular, and functional remodeling in response to injury, disease, or infection of the central nervous system, as evident in neurodegenerative diseases. Astroglial mediated inflammation plays a prominent role in the pathogenesis of neurodegenerative diseases. This review focus on the role of astrocytes as essential players in neuroinflammation and discuss their morphological and functional heterogeneity in the normal central nervous system and explore the spatial and temporal variations in astroglial phenotypes observed under different disease conditions. This review discusses the intimate relationship of astrocytes to pathological hallmarks of neurodegenerative diseases. Finally, this review considers the putative therapeutic strategies that can be deployed to modulate the astroglial functions in neurodegenerative diseases. HIGHLIGHTS: Astroglia mediated neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. Activated astrocytes exhibit diverse phenotypes in a region-specific manner in brain and interact with β-amyloid, tau, and α-synuclein species as well as with microglia and neuronal circuits. Activated astrocytes are likely to influence the trajectory of disease progression of neurodegenerative diseases, as determined by the stage of disease, individual susceptibility, and state of astroglial priming. Modulation of astroglial activation may be a therapeutic strategy at various stages in the trajectory of neurodegenerative diseases to modify the disease course.
AU  - Edison,P
DO  - 10.1002/alz.13678
PY  - 2024///
TI  - Astroglial activation: Current concepts and future directions.
T2  - Alzheimers Dement
UR  - http://dx.doi.org/10.1002/alz.13678
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38305570
ER  -
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