Imperial College London
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Professor Paul Edison

Faculty of Medicine, Department of Brain Sciences

Professor of Neuroscience
 
 
 
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Contact

 

paul.edison

 
 
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Location

 

2S 5A, Level 2Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alagaratnam:2024:10.1007/s13365-024-01200-3,
author = {Alagaratnam, J and Thornhill, JP and Fan, Z and Vera, JH and Underwood, J and Hall, R and Searle, G and Owen, D and Edison, P and Fidler, S and Winston, A},
doi = {10.1007/s13365-024-01200-3},
journal = {Journal of NeuroVirology},
title = {Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study},
url = {http://dx.doi.org/10.1007/s13365-024-01200-3},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Persistent inflammation is described in people with HIV (PWH) on antiretroviral treatment (ART). Early ART initiation is associated with reduced inflammation. We aimed to evaluate neuroinflammation, using translocator protein (TSPO) [11C]PBR28 PET neuroimaging in PWH who initiated ART during acute HIV (aPWH) versus chronic HIV infection (cPWH) versus a control population. This was a cross-sectional, observational study. All participants underwent [11C]PBR28 PET-CT neuroimaging. Using a two-tissue compartment model, total volume of distribution (VT) and distribution volume ratios (DVR) using cortical grey matter as a pseudo-reference region at 20 regions of interest (ROIs) were calculated. Differences in VT and DVR were compared between groups using the Kruskall-Wallis test. Seventeen neuro-asymptomatic male PWH on ART (9 aPWH, 8 cPWH) and 8 male control participants (CPs) were included. Median (interquartile range, IQR) age was 40 (30, 46), 44 (41, 47) and 21 (20, 25) years in aPWH, cPWH and CPs, respectively. Median (IQR) CD4 (cells/µL) and CD4:CD8 were 687 (652, 1014) and 1.37 (1.24, 1.42), and 700 (500, 720) and 0.67 (0.64, 0.82) in aPWH and cPWH, respectively. Overall, no significant difference in VT and DVR were observed between the three groups at any ROIs. cPWH demonstrated a trend towards higher mean VT compared with aPWH and CPs at most ROIs. No significant differences in neuroinflammation, using [11C]PBR28 binding as a proxy, were identified between cPWH, aPWH and CPs. A trend towards lower absolute [11C]PBR28 binding was seen amongst aPWH and CPs, suggesting early ART may mitigate neuroinflammation.
AU  - Alagaratnam,J
AU  - Thornhill,JP
AU  - Fan,Z
AU  - Vera,JH
AU  - Underwood,J
AU  - Hall,R
AU  - Searle,G
AU  - Owen,D
AU  - Edison,P
AU  - Fidler,S
AU  - Winston,A
DO  - 10.1007/s13365-024-01200-3
PY  - 2024///
SN  - 1355-0284
TI  - Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study
T2  - Journal of NeuroVirology
UR  - http://dx.doi.org/10.1007/s13365-024-01200-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38575831
UR  - http://hdl.handle.net/10044/1/110863
ER  -
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