Imperial College London
Alternate

Professor Richard Reynolds, BSc AKC PhD

Faculty of Medicine, Department of Brain Sciences

Professor of Cellular Neurobiology
 
 
 
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Contact

 

+44 (0)20 7594 6668r.reynolds

 
 
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Location

 

E414Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reynolds:2001:10.1016/s0079-6123(01)32073-3,
author = {Reynolds, R and Cenci, di Bello I and Dawson, M and Levine, J},
doi = {10.1016/s0079-6123(01)32073-3},
journal = {Prog Brain Res},
pages = {165--174},
title = {The response of adult oligodendrocyte progenitors to demyelination in EAE.},
url = {http://dx.doi.org/10.1016/s0079-6123(01)32073-3},
volume = {132},
year = {2001}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cells with the phenotypic characteristics of oligodendrocyte progenitors (NG2+/PDGF alpha R+/O4+) are found throughout the adult mammalian CNS in numbers similar to microglia. They are a reactive glial cell population and respond to demyelination by increasing in number, thereby repopulating the lesion site with cells capable of differentiating into remyelinating oligodendrocytes. Direct evidence that they differentiate into remyelinating cells is missing, although this is the most likely scenario. Cells with the same phenotype are found in normal human CNS tissue and also in chronic MS lesions. Further studies on this intriguing cell type are necessary in order to understand the molecular signals involved in their reaction to injury, particularly in multiple sclerosis.
AU  - Reynolds,R
AU  - Cenci,di Bello I
AU  - Dawson,M
AU  - Levine,J
DO  - 10.1016/s0079-6123(01)32073-3
EP  - 174
PY  - 2001///
SN  - 0079-6123
SP  - 165
TI  - The response of adult oligodendrocyte progenitors to demyelination in EAE.
T2  - Prog Brain Res
UR  - http://dx.doi.org/10.1016/s0079-6123(01)32073-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/11544985
VL  - 132
ER  -
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