Imperial College London
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DrRyanThwaites

Faculty of Medicine, National Heart & Lung Institute

Lecturer in Respiratory Immunology
 
 
 
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r.thwaites

 
 
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Respiratory InfectionsMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jackson:2023:10.1016/S2213-2600(23)00124-8,
author = {Jackson, C and Stewart, ID and Plekhanova, T and Cunningham, PS and Hazel, AL and Al-Sheklly, B and Aul, R and Bolton, CE and Chalder, T and Chalmers, JD and Chaudhuri, N and Docherty, AB and Donaldson, G and Edwardson, CL and Elneima, O and Greening, NJ and Hanley, NA and Harris, VC and Harrison, EM and Ho, L-P and Houchen-Wolloff, L and Howard, LS and Jolley, CJ and Jones, MG and Leavy, OC and Lewis, KE and Lone, NI and Marks, M and McAuley, HJC and McNarry, MA and Patel, BV and Piper-Hanley, K and Poinasamy, K and Raman, B and Richardson, M and Rivera-Ortega, P and Rowland-Jones, SL and Rowlands, AV and Saunders, RM and Scott, JT and Sereno, M and Shah, AM and Shikotra, A and Singapuri, A and Stanel, SC and Thorpe, M and Wootton, DG and Yates, T and Gisli, Jenkins R and Singh, SJ and Man, WD-C and Brightling, CE and Wain, LV and Porter, JC and Thompson, AAR and Horsley, A and Molyneaux, PL and Evans, RA and Jones, SE and Rutter, MK and Blaikley, JF and PHOSP-COVID, Study Collaborati},
doi = {10.1016/S2213-2600(23)00124-8},
journal = {The Lancet Respiratory Medicine},
pages = {673--684},
title = {Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study},
url = {http://dx.doi.org/10.1016/S2213-2600(23)00124-8},
volume = {11},
year = {2023}
}
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TY  - JOUR
AB  - BACKGROUND: Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. We aimed to investigate the prevalence and nature of sleep disturbance after discharge following hospital admission for COVID-19 and to assess whether this was associated with dyspnoea. METHODS: CircCOVID was a prospective multicentre cohort substudy designed to investigate the effects of circadian disruption and sleep disturbance on recovery after COVID-19 in a cohort of participants aged 18 years or older, admitted to hospital for COVID-19 in the UK, and discharged between March, 2020, and October, 2021. Participants were recruited from the Post-hospitalisation COVID-19 study (PHOSP-COVID). Follow-up data were collected at two timepoints: an early time point 2-7 months after hospital discharge and a later time point 10-14 months after hospital discharge. Sleep quality was assessed subjectively using the Pittsburgh Sleep Quality Index questionnaire and a numerical rating scale. Sleep quality was also assessed with an accelerometer worn on the wrist (actigraphy) for 14 days. Participants were also clinically phenotyped, including assessment of symptoms (ie, anxiety [Generalised Anxiety Disorder 7-item scale questionnaire], muscle function [SARC-F questionnaire], dyspnoea [Dyspnoea-12 questionnaire] and measurement of lung function), at the early timepoint after discharge. Actigraphy results were also compared to a matched UK Biobank cohort (non-hospitalised individuals and recently hospitalised individuals). Multivariable linear regression was used to define associations of sleep disturbance with the primary outcome of breathlessness and the other clinical symptoms. PHOSP-COVID is registered on the ISRCTN Registry (ISRCTN10980107). FINDINGS: 2320 of 2468 participants in the PHOSP-COVID study attended
AU  - Jackson,C
AU  - Stewart,ID
AU  - Plekhanova,T
AU  - Cunningham,PS
AU  - Hazel,AL
AU  - Al-Sheklly,B
AU  - Aul,R
AU  - Bolton,CE
AU  - Chalder,T
AU  - Chalmers,JD
AU  - Chaudhuri,N
AU  - Docherty,AB
AU  - Donaldson,G
AU  - Edwardson,CL
AU  - Elneima,O
AU  - Greening,NJ
AU  - Hanley,NA
AU  - Harris,VC
AU  - Harrison,EM
AU  - Ho,L-P
AU  - Houchen-Wolloff,L
AU  - Howard,LS
AU  - Jolley,CJ
AU  - Jones,MG
AU  - Leavy,OC
AU  - Lewis,KE
AU  - Lone,NI
AU  - Marks,M
AU  - McAuley,HJC
AU  - McNarry,MA
AU  - Patel,BV
AU  - Piper-Hanley,K
AU  - Poinasamy,K
AU  - Raman,B
AU  - Richardson,M
AU  - Rivera-Ortega,P
AU  - Rowland-Jones,SL
AU  - Rowlands,AV
AU  - Saunders,RM
AU  - Scott,JT
AU  - Sereno,M
AU  - Shah,AM
AU  - Shikotra,A
AU  - Singapuri,A
AU  - Stanel,SC
AU  - Thorpe,M
AU  - Wootton,DG
AU  - Yates,T
AU  - Gisli,Jenkins R
AU  - Singh,SJ
AU  - Man,WD-C
AU  - Brightling,CE
AU  - Wain,LV
AU  - Porter,JC
AU  - Thompson,AAR
AU  - Horsley,A
AU  - Molyneaux,PL
AU  - Evans,RA
AU  - Jones,SE
AU  - Rutter,MK
AU  - Blaikley,JF
AU  - PHOSP-COVID,Study Collaborative Group
DO  - 10.1016/S2213-2600(23)00124-8
EP  - 684
PY  - 2023///
SN  - 2213-2600
SP  - 673
TI  - Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
T2  - The Lancet Respiratory Medicine
UR  - http://dx.doi.org/10.1016/S2213-2600(23)00124-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37072018
UR  - https://www.sciencedirect.com/science/article/pii/S2213260023001248
UR  - http://hdl.handle.net/10044/1/103507
VL  - 11
ER  -
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