Imperial College London
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Dr Sara De Matteis

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

s.de-matteis

 
 
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Location

 

G51Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Broccia:2023:10.1177/10732748231202906,
author = {Broccia, G and Carter, J and Ozsin-Ozler, C and De, Matteis S and Cocco, P},
doi = {10.1177/10732748231202906},
journal = {Cancer Control},
title = {Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy.},
url = {http://dx.doi.org/10.1177/10732748231202906},
volume = {30},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The epidemiology of myeloid hematologic malignancies in Italy has been poorly investigated. METHODS: We used a validated database of 1974-2003 incident cases of hematologic malignancies among the resident population (all ages) of Sardinia, Italy, to describe the incidence of myeloid malignancies overall (N = 4389 cases) and by subtype. We investigated the time trend of acute myeloid leukemia (N = 1227 cases), chronic myeloid leukemia (N = 613 cases), and myelodysplastic syndrome (N = 1296 cases), and used Bayesian methods to explore their geographic spread, and Poisson regression analysis to estimate their association with environmental and socio-economic factors. RESULTS: The annual standardized (world population) incidence rate (IR) of myeloid malignancies over the study period was 6.5 per 100,000 (95% CI 6.2-6.7). Myelodysplastic syndromes were the most prevalent subgroup (IR = 1.7, 95% CI 1.5-1.8). Incidence of all myeloid malignancies combined increased sharply during the study period with an annual percent change (APC) of 10.06% (95% CI 9.51-10.61), 19.77% for myelodysplastic syndromes (95% CI 19.63-19.91), and 3.18% (95% CI 2.99-3.37) for acute myeloid leukemia. Chronic myeloid leukemia did not show an upward trend. Apart from sporadic excesses in small rural communities and the major urban area, there was no evidence of spatial clustering. The risk of myeloid malignancies increased with increasing prevalence of sheep breeding. CONCLUSIONS: Our results might prompt further research on the local genetic and environmental determinants of myeloid hematologic malignancies.
AU  - Broccia,G
AU  - Carter,J
AU  - Ozsin-Ozler,C
AU  - De,Matteis S
AU  - Cocco,P
DO  - 10.1177/10732748231202906
PY  - 2023///
TI  - Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy.
T2  - Cancer Control
UR  - http://dx.doi.org/10.1177/10732748231202906
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37877513
VL  - 30
ER  -
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