Imperial College London
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Dr Sara De Matteis

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

s.de-matteis

 
 
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Location

 

G51Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mukhopadhyay:2024:10.1016/j.pulmoe.2024.02.002,
author = {Mukhopadhyay, D and Cocco, P and Orrù, S and Cherchi, R and De, Matteis S},
doi = {10.1016/j.pulmoe.2024.02.002},
journal = {Pulmonology},
title = {The role of MicroRNAs as early biomarkers of asbestos-related lung cancer: A systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1016/j.pulmoe.2024.02.002},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Asbestos is still the leading cause of occupational cancer mortality worldwide. Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, so early diagnosis biomarkers are needed. MicroRNAs (miRNAs) have been proposed as potential early diagnostic biomarkers of asbestos-related LC and MPM. AIM: To evaluate the role of miRNAs as diagnostic and prognostic biomarkers of asbestos-related LC and MPM by performing a literature systematic review and meta-analysis. METHODS: MEDLINE, EMBASE via Ovid, PUBMED and Cochrane library databases were systematically searched up to April 2023 to identify relevant articles. A grey literature search was also conducted using the Google Scholar platform. MeSH and free text terms for 'asbestos', 'occupational exposure', 'lung cancer', 'mesothelioma' and 'miRNAs' were used to search the literature. Our systematic review protocol was registered in the PROSPERO database. Study quality was assessed via the Newcastle-Ottawa Scale. RESULTS: From the search, 331 articles were retrieved, and, after applying our selection criteria, and exclusion of one study for poor quality, 27 studies were included in the review. Most of the studies were hospital-based case-control, conducted in Europe, and evaluated MPM among men only. MiRNAs expression was measured mainly in plasma or serum. MiR-126, miR-132-3p, and miR-103a-3p were the most promising diagnostic biomarkers for MPM, and we estimated a pooled area under the curve (AUC) of 85 %, 73 %, and 50 %, respectively. In relation to MPM prognosis, miR-1973p resulted associated with increased survival time. MiR-126, alone and combined with miR-222, was confirmed associated also to LC diagnosis, together with miR-1254 and miR-574-5p; no miRNA was found associated to LC prognosis. CONCLUSION: Based on our systematic literature review there is suggestive evidence that the expression of specific miRNAs in the blood serum or plasm
AU  - Mukhopadhyay,D
AU  - Cocco,P
AU  - Orrù,S
AU  - Cherchi,R
AU  - De,Matteis S
DO  - 10.1016/j.pulmoe.2024.02.002
PY  - 2024///
TI  - The role of MicroRNAs as early biomarkers of asbestos-related lung cancer: A systematic review and meta-analysis.
T2  - Pulmonology
UR  - http://dx.doi.org/10.1016/j.pulmoe.2024.02.002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38402124
ER  -
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