Imperial College London

Tony D. Southall

Faculty of Natural SciencesDepartment of Life Sciences

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5338t.southall

 
 
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Location

 

220 off lab 216Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

Research Interests and Techniques

I am interested in how neuronal properties are specified and maintained in the developing and adult nervous system. Gaining a comprehensive understanding of gene regulatory networks that specify neuronal fate will provide methods for reprogramming neuronal properties in vivo.

This research utilises the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of transcriptional regulators, in specific neuronal populations.

For more information, please see the lab website

Confocal images

Publications

Journals

Marshall OJ, Southall TD, Cheetham SW, et al., 2016, Cell-type-specific profiling of protein-DNA interactions without cell isolation using targeted DamID with next-generation sequencing, Nature Protocols, Vol:11, ISSN:1754-2189, Pages:1586-1598

Aughey GN, Southall TD, 2016, Dam it's good! DamID profiling of protein-DNA interactions, Wiley Interdisciplinary Reviews-developmental Biology, Vol:5, ISSN:1759-7684, Pages:25-37

Cattenoz PB, Popkova A, Southall TD, et al., 2016, Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila, Genetics, Vol:202, ISSN:0016-6731, Pages:191-+

McClure CD, Southall TD, 2015, Getting Down to Specifics: Profiling Gene Expression and Protein-DNA Interactions in a Cell Type-Specific Manner, Advances in Genetics, Vol 91, Vol:91, ISSN:0065-2660, Pages:103-151

Southall TD, Davidson CM, Miller C, et al., 2014, Dedifferentiation of Neurons Precedes Tumor Formation in lola Mutants, Developmental Cell, Vol:28, ISSN:1534-5807, Pages:685-696

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