Imperial College London

Tony D. Southall

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer



+44 (0)20 7594 5338t.southall




220 off lab 216Sir Ernst Chain BuildingSouth Kensington Campus





Research Interests and Techniques

I am interested in how neuronal properties are specified and maintained in the developing and adult nervous system. Gaining a comprehensive understanding of gene regulatory networks that specify neuronal fate will provide methods for reprogramming neuronal properties in vivo.

This research utilises the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of transcriptional regulators, in specific neuronal populations.

For more information, please see the lab website

Confocal images



Cheetham SW, Gruhn WH, van den Ameele J, et al., 2018, Targeted DamID reveals differential binding of mammalian pluripotency factors., Development

Aughey GN, Gomez AE, Thomson J, et al., 2018, CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo, Elife, Vol:7, ISSN:2050-084X

Dinges N, Morin V, Kreim N, et al., 2017, Comprehensive Characterization of the Complex lola Locus Reveals a Novel Role in the Octopaminergic Pathway via Tyramine Beta-Hydroxylase Regulation, Cell Reports, Vol:21, ISSN:2211-1247, Pages:2911-2925

Marshall OJ, Southall TD, Cheetham SW, et al., 2016, Cell-type-specific profiling of protein-DNA interactions without cell isolation using targeted DamID with next-generation sequencing, Nature Protocols, Vol:11, ISSN:1754-2189, Pages:1586-1598

Aughey GN, Southall TD, 2016, Dam it's good! DamID profiling of protein-DNA interactions, Wiley Interdisciplinary Reviews-developmental Biology, Vol:5, ISSN:1759-7684, Pages:25-37

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