Imperial College London

Tony D. Southall

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 5338t.southall

 
 
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Location

 

220 off lab 216Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

Research Interests and Techniques

I am interested in how neuronal properties are specified and maintained in the developing and adult nervous system. Gaining a comprehensive understanding of gene regulatory networks that specify neuronal fate will provide methods for reprogramming neuronal properties in vivo.

This research utilises the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of transcriptional regulators, in specific neuronal populations.

For more information, please see the lab website

Confocal images

Publications

Journals

Mundorf J, Donohoe CD, McClure CD, et al., 2019, Ets21c governs tissue renewal, stress tolerance, and aging in the drosophila intestine, Cell Reports, Vol:27, ISSN:2211-1247, Pages:3019-3033.e5

Sharrock J, Estacio Gomez A, Jacobson J, et al., 2019, fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila, Disease Models & Mechanisms, Vol:12, ISSN:1754-8403

Southall T, Aughey G, Cheetham S, 2019, DamID as a versatile tool for understanding gene regulation, Development, Vol:146, ISSN:0950-1991

Sen SQ, Chanchani S, Southall TD, et al., 2019, Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci, Elife, Vol:8, ISSN:2050-084X

Cheetham SW, Gruhn WH, van den Ameele J, et al., 2018, Targeted DamID reveals differential binding of mammalian pluripotency factors, Development, Vol:145, ISSN:0950-1991

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