Research Interests and Techniques
I am interested in how neuronal properties are specified and maintained in the developing and adult nervous system. Gaining a comprehensive understanding of gene regulatory networks that specify neuronal fate will provide methods for reprogramming neuronal properties in vivo.
This research utilises the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of transcriptional regulators, in specific neuronal populations.
For more information, please see the lab website.
et al., 2019, Ets21c governs tissue renewal, stress tolerance, and aging in the drosophila intestine, Cell Reports, Vol:27, ISSN:2211-1247, Pages:3019-3033.e5
et al., 2019, fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila, Disease Models & Mechanisms, Vol:12, ISSN:1754-8403
Southall T, Aughey G, Cheetham S, 2019, DamID as a versatile tool for understanding gene regulation, Development, Vol:146, ISSN:0950-1991
et al., 2019, Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci, Elife, Vol:8, ISSN:2050-084X
et al., 2018, Targeted DamID reveals differential binding of mammalian pluripotency factors, Development, Vol:145, ISSN:0950-1991