Summary
Research Interests and Techniques
My lab is interested in how chromatin remodelling and gene regulatory networks drive the maturation and differentiation of neurons in the developing nervous system. When a neuron is born, it still has a long way to go before it is a full functional unit in the nervous system. Much has been learnt about the cellular changes that a neuron undergoes as it matures, however, much less is known about the chromatin remodelling process that are occurring during neuronal maturation. Our recent paper in eLife (Hassan et al., 2020) implicates a component of the condensin complex in this process.
We use the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of regulatory factors, and have also developed CATaDa for profiling chromatin accessibility in vivo in a cell-specific manner (Aughey et al., 2018)
For more information, please see the lab website.
Publications
Journals
Aughey G, Grimes K, Forsberg E, et al., 2023, NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturation, Embo Reports, Vol:24, ISSN:1469-221X, Pages:1-15
Martinez Corrales G, Li M, Svermova T, et al., 2022, Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1, Nature Aging, Vol:2, ISSN:2662-8465, Pages:1176-1190
Grimes K, Beckwith EJ, Pearson WH, et al., 2022, A serine-folate metabolic unit controls resistance and tolerance of infection
Demarco RS, Stack BJ, Tang AM, et al., 2022, Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila, Cell Reports, Vol:39, ISSN:2211-1247, Pages:1-20
McClure C, Aughey G, Hassan A, et al., 2022, An auxin-inducible, GAL4-compatible, gene expression system for Drosophila, Elife, Vol:11, ISSN:2050-084X, Pages:1-18