Imperial College London
Alternate

DrVassoTerzidou

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Reader in Obstetrics and Gynaecology
 
 
 
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Contact

 

+44 (0)20 7594 2164v.terzidou

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ridout:2019:10.1016/j.ajog.2019.05.032,
author = {Ridout, AE and Ibeto, L and Ross, G and Cook, JR and Sykes, L and David, AL and Seed, PT and Tribe, R and Bennett, PR and Terzidou, V and Shennan, AH and Chandiramani, M and Collaborators and Brown, R and Chatfield, S and Sadeh, D},
doi = {10.1016/j.ajog.2019.05.032},
journal = {American Journal of Obstetrics and Gynecology},
pages = {341.e1--341.e9},
title = {Cervical length and quantitative fetal fibronectin in the prediction of spontaneous preterm birth in asymptomatic women with congenital uterine anomaly},
url = {http://dx.doi.org/10.1016/j.ajog.2019.05.032},
volume = {221},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Congenital uterine anomalies (CUA) are associated with late miscarriage and spontaneous preterm birth (sPTB). OBJECTIVES: Our aim was to 1) determine the rate of sPTB in each type of CUA and 2) assess the performance of quantitative fetal fibronectin (qfFN) and transvaginal cervical length (CL) measurement by ultrasound in asymptomatic women with CUA for the prediction of sPTB at <34 and <37 weeks of gestation. STUDY DESIGN: This was a retrospective cohort of women with CUA asymptomatic for sPTB, from four UK tertiary referral centres (2001-2016). CUAs were categorised into fusion (unicornuate, didelphic and bicornuate uteri) or resorption defects (septate, with or without resection and arcuate uteri), based on pre-pregnancy diagnosis. All women underwent serial transvaginal ultrasound CL assessment in the second trimester (16 to 24 weeks' gestation); a subgroup underwent qfFN testing from 18 weeks' gestation. We investigated the relationship between CUA and predictive test performance for sPTB before 34 and 37 weeks' gestation. RESULTS: Three hundred and nineteen women were identified as having CUA within our high-risk population. 7% (23/319) delivered spontaneously <34 weeks, and 18% (56/319) <37 weeks' gestation. Rates of sPTB by type were: 26% (7/27) for unicornuate, 21% (7/34) for didelphic, 16% (31/189) for bicornuate, 13% (7/56) for septate and 31% (4/13) for arcuate. 80% (45/56) of women who had sPTB <37 weeks did not develop a short CL (<25 mm) during the surveillance period (16-24 weeks). The diagnostic accuracy of short CL had low sensitivity (20.3) for predicting sPTB <34 weeks. Cervical Length had ROC AUC of 0.56 (95% CI 0.48 to 0.64) and 0.59 (95% CI 0.55 to 0.64) for prediction of sPTB <34 and 37 weeks' respectively. The AUC for CL to predict sPTB <34 weeks was 0.48 for fusion defects (95% CI 0.39 to 0.57) but 0.78 (95% CI 0.66 to 0.91) for women with resorption defects. Overall quantitative fetal fibronectin had
AU  - Ridout,AE
AU  - Ibeto,L
AU  - Ross,G
AU  - Cook,JR
AU  - Sykes,L
AU  - David,AL
AU  - Seed,PT
AU  - Tribe,R
AU  - Bennett,PR
AU  - Terzidou,V
AU  - Shennan,AH
AU  - Chandiramani,M
AU  - Collaborators
AU  - Brown,R
AU  - Chatfield,S
AU  - Sadeh,D
DO  - 10.1016/j.ajog.2019.05.032
EP  - 1
PY  - 2019///
SN  - 0002-9378
SP  - 341
TI  - Cervical length and quantitative fetal fibronectin in the prediction of spontaneous preterm birth in asymptomatic women with congenital uterine anomaly
T2  - American Journal of Obstetrics and Gynecology
UR  - http://dx.doi.org/10.1016/j.ajog.2019.05.032
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31132343
UR  - https://www.sciencedirect.com/science/article/pii/S0002937819307045?via%3Dihub
UR  - http://hdl.handle.net/10044/1/71455
VL  - 221
ER  -
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