Imperial College London
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Prof. William Wisden F. Med. Sci.

Faculty of Natural Sciences, Department of Life Sciences

Chair in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 9744w.wisden Website CV

 
 
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Location

 

401BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sommer:1990,
author = {Sommer, B and Keinanen, K and Verdoorn, TA and Wisden, W and Burnashev, N and Herb, A and Kohler, M and Takagi, T and Sakmann, B and Seeburg, PH},
journal = {Science},
pages = {1580--1585},
title = {Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1699275},
volume = {249},
year = {1990}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In the central nervous system (CNS), the principal mediators of fast synaptic excitatory neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). In each member of a family of four abundant AMPA receptors, a small segment preceding the predicted fourth transmembrane region has been shown to exist in two versions with different amino acid sequences. These modules, designated "flip" and "flop," are encoded by adjacent exons of the receptor genes and impart different pharmacological and kinetic properties on currents evoked by L-glutamate or AMPA, but not those evoked by kainate. For each receptor, the alternatively spliced messenger RNAs show distinct expression patterns in rat brain, particularly in the CA1 and CA3 fields of the hippocampus. These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.
AU  - Sommer,B
AU  - Keinanen,K
AU  - Verdoorn,TA
AU  - Wisden,W
AU  - Burnashev,N
AU  - Herb,A
AU  - Kohler,M
AU  - Takagi,T
AU  - Sakmann,B
AU  - Seeburg,PH
EP  - 1585
PY  - 1990///
SN  - 0036-8075
SP  - 1580
TI  - Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
T2  - Science
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1699275
VL  - 249
ER  -
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