Imperial College London
Alternate

Professor Xiao Yun Xu

Faculty of Engineering, Department of Chemical Engineering

Professor, Biofluid Mechanics & Director of Graduate School
 
 
 
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Contact

 

yun.xu Website

 
 
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Location

 

407ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chong:2022:10.1007/s10237-021-01534-5,
author = {Chong, MY and Gu, B and Armour, C and Dokos, S and Ong, ZC and Xu, X and Lim, E},
doi = {10.1007/s10237-021-01534-5},
journal = {Biomechanics and Modeling in Mechanobiology},
pages = {261--275},
title = {An integrated fluid-structure interaction and thrombosis model for type B aortic dissection},
url = {http://dx.doi.org/10.1007/s10237-021-01534-5},
volume = {21},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - False lumen thrombosis (FLT) in type B aortic dissection has been associated with theprogression of dissection and treatment outcome. Existing computational models mostlyassume rigid wall behaviour which ignores the effect of flap motion on flow and thrombusformation within the FL. In this study, we have combined a fully coupled fluid-structureinteraction (FSI) approach with a shear-driven thrombosis model described by a series ofconvection-diffusion reaction equations. The integrated FSI-thrombosis model has beenapplied to an idealised dissection geometry to investigate the interaction between vessel wallmotion and growing thrombus. Our simulation results show that wall compliance and flapmotion can influence the progression of FLT. The main difference between the rigid and FSImodels is the continuous development of vortices near the tears caused by drastic flap motionup to 4.45 mm. Flap-induced high shear stress and shear rates around tears help to transportactivated platelets further to the neighbouring region, thus speeding up thrombus formationduring the accelerated phase in the FSI models. Reducing flap mobility by increasing theYoung’s modulus of the flap slows down the thrombus growth. Compared to the rigid model,the predicted thrombus volume is 25 % larger using the FSI-thrombosis model with a relativelymobile flap. Furthermore, our FSI-thrombosis model can capture the gradual effect of thrombusgrowth on the flow field, leading to flow obstruction in the FL, increased blood viscosity andreduced flap motion. This model is a step closer towards simulating realistic thrombus growthin aortic dissection, by taking into account the effect of intimal flap and vessel wall motion.
AU  - Chong,MY
AU  - Gu,B
AU  - Armour,C
AU  - Dokos,S
AU  - Ong,ZC
AU  - Xu,X
AU  - Lim,E
DO  - 10.1007/s10237-021-01534-5
EP  - 275
PY  - 2022///
SN  - 1617-7940
SP  - 261
TI  - An integrated fluid-structure interaction and thrombosis model for type B aortic dissection
T2  - Biomechanics and Modeling in Mechanobiology
UR  - http://dx.doi.org/10.1007/s10237-021-01534-5
UR  - https://link.springer.com/article/10.1007/s10237-021-01534-5
UR  - http://hdl.handle.net/10044/1/92651
VL  - 21
ER  -
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