Imperial College London
Alternate

Professor Xiao Yun Xu

Faculty of Engineering, Department of Chemical Engineering

Professor, Biofluid Mechanics & Director of Graduate School
 
 
 
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Contact

 

yun.xu Website

 
 
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Location

 

407ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Watson:2024:10.1007/s10439-023-03390-z,
author = {Watson, C and Saaid, H and Vedula, V and Cardenas, JC and Henke, PK and Nicoud, F and Xu, XY and Hunt, BJ and Manning, KB},
doi = {10.1007/s10439-023-03390-z},
journal = {Ann Biomed Eng},
pages = {467--486},
title = {Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling.},
url = {http://dx.doi.org/10.1007/s10439-023-03390-z},
volume = {52},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Venous thromboembolism (VTE) is a massive clinical challenge, annually affecting millions of patients globally. VTE is a particularly consequential pathology, as incidence is correlated with extremely common risk factors, and a large cohort of patients experience recurrent VTE after initial intervention. Altered hemodynamics, hypercoagulability, and damaged vascular tissue cause deep-vein thrombosis and pulmonary embolism, the two permutations of VTE. Venous valves have been identified as likely locations for initial blood clot formation, but the exact pathway by which thrombosis occurs in this environment is not entirely clear. Several risk factors are known to increase the likelihood of VTE, particularly those that increase inflammation and coagulability, increase venous resistance, and damage the endothelial lining. While these risk factors are useful as predictive tools, VTE diagnosis prior to presentation of outward symptoms is difficult, chiefly due to challenges in successfully imaging deep-vein thrombi. Clinically, VTE can be managed by anticoagulants or mechanical intervention. Recently, direct oral anticoagulants and catheter-directed thrombolysis have emerged as leading tools in resolution of venous thrombosis. While a satisfactory VTE model has yet to be developed, recent strides have been made in advancing in silico models of venous hemodynamics, hemorheology, fluid-structure interaction, and clot growth. These models are often guided by imaging-informed boundary conditions or inspired by benchtop animal models. These gaps in knowledge are critical targets to address necessary improvements in prediction and diagnosis, clinical management, and VTE experimental and computational models.
AU  - Watson,C
AU  - Saaid,H
AU  - Vedula,V
AU  - Cardenas,JC
AU  - Henke,PK
AU  - Nicoud,F
AU  - Xu,XY
AU  - Hunt,BJ
AU  - Manning,KB
DO  - 10.1007/s10439-023-03390-z
EP  - 486
PY  - 2024///
SP  - 467
TI  - Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling.
T2  - Ann Biomed Eng
UR  - http://dx.doi.org/10.1007/s10439-023-03390-z
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37914979
VL  - 52
ER  -
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