Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleThayyil S, Shankaran S, Wade A, et al., 2013,
Whole-body cooling in neonatal encephalopathy using phase changing material
, ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 98, Pages: F280-F281, ISSN: 1359-2998- Author Web Link
- Cite
- Citations: 35
-
Journal articleArthurs OJ, Thayyil S, Wade A, et al., 2013,
Normal ascent of the conus medullaris: a post-mortem foetal MRI study
, JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 26, Pages: 697-702, ISSN: 1476-7058- Author Web Link
- Cite
- Citations: 20
-
Journal articleBen-Sasi K, Chitty LS, Franck LS, et al., 2013,
Acceptability of a minimally invasive perinatal/paediatric autopsy: healthcare professionals' views and implications for practice
, PRENATAL DIAGNOSIS, Vol: 33, Pages: 307-312, ISSN: 0197-3851- Author Web Link
- Cite
- Citations: 59
-
Journal articlePauliah SS, Shankaran S, Wade A, et al., 2013,
Therapeutic hypothermia for neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis
, PLoS ONE, Vol: 8, ISSN: 1932-6203Although selective or whole body cooling combined with optimal intensive care improves outcomes following neonatal encephalopathy in high-income countries, the safety and efficacy of cooling in low-and middle-income countries is not known.Objective:We performed a systematic review and meta-analysis of all published randomised or quasi-randomised controlled trials of cooling therapy for neonatal encephalopathy in low-and middle-income countries.Results:Seven trials, comprising a total of 567 infants were included in the meta-analysis. Most study infants had mild (15%) or moderate encephalopathy (48%) and did not receive invasive ventilation (88%). Cooling devices included water-circulating cooling caps, frozen gel packs, ice, water bottles, and phase-changing material. No statistically significant reduction in neonatal mortality was seen with cooling (risk ratio: 0.74, 95% confidence intervals: 0.44 to 1.25). Data on other neonatal morbidities and long-term neurological outcomes were insufficient.Conclusion:Cooling therapy was not associated with a statistically significant reduction in neonatal mortality in low-and middle-income countries although the confidence intervals were wide and not incompatible with results seen in high-income countries. The apparent lack of treatment effect may be due to the heterogeneity and poor quality of the included studies, inefficiency of the low technology cooling devices, lack of optimal neonatal intensive care, sedation and ventilatory support, overuse of oxygen, or may be due to the intrinsic difference in the population, for example higher rates of perinatal infection, obstructed labor, intrauterine growth retardation and maternal malnutrition. Evaluation of the safety and efficacy of cooling in adequately powered randomised controlled trials is required before cooling is offered in routine clinical practice in low-and middle-income countries.
-
Journal articleSoe A, Apampa B, Fernando B, et al., 2013,
Interventions for reducing medication errors in children in hospital
, Cochrane Database of Systematic Reviews, Vol: 2013, ISSN: 1465-1858This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the effectiveness of interventions to reduce medication errors (MEs) in hospitalised children.
-
Journal articleThayyil S, Sebire NJ, Chitty LS, 2013,
Erratum: Post-mortem MRI versus conventional autopsy in fetuses and children: A prospective validation study (Lancet (2013) 382 (223-233))
, The Lancet, Vol: 382, ISSN: 0140-6736- Cite
- Citations: 1
-
Journal articleAddison S, Sebire NJ, Taylor AM, et al., 2012,
High quality genomic DNA extraction from postmortem fetal tissue
, JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 25, Pages: 2467-2469, ISSN: 1476-7058- Author Web Link
- Cite
- Citations: 5
-
Journal articleArthurs O, Thayyil S, Wade A, et al., 2012,
MR determination of neonatal spinal canal depth
, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 81, Pages: E813-E816, ISSN: 0720-048X- Author Web Link
- Cite
- Citations: 1
-
Journal articleSebire NJ, Weber MA, Thayyil S, et al., 2012,
Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination ("keyhole autopsy"): feasibility and initial experience
, JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 25, Pages: 513-518, ISSN: 1476-7058- Author Web Link
- Cite
- Citations: 64
-
Journal articleThayyil S, De Vita E, Sebire NJ, et al., 2012,
Post-mortem cerebral magnetic resonance imaging <i>T</i><sub>1</sub> and <i>T</i><sub>2</sub> in fetuses, newborns and infants
, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 81, Pages: E232-E238, ISSN: 0720-048X- Author Web Link
- Cite
- Citations: 25
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.
Contact us
Centre for Perinatal Neuroscience
Department of Brain Sciences
5th Floor, Hammersmith House
Hammersmith Hospital
Du Cane Road
London, W12 0HS
Ms Martin, Caroline J
Clinical Trials Manager, Centre for Perinatal Neuroscience
Room 515, Hammersmith House
+44 (0) 78 1753 2977
c.martin1@imperial.ac.uk