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  • JOURNAL ARTICLE
    Bogle IDL, Cockshott AR, Bulmer M, Thornhill N, Gregory M, Dehghani Met al., 1996,

    A process systems engineering view of biochemical process operations

    , COMPUTERS & CHEMICAL ENGINEERING, Vol: 20, Pages: 943-949, ISSN: 0098-1354
  • JOURNAL ARTICLE
    Dehghani M, Bulmer M, Gregory ME, Ison AP, Thornhill NFet al., 1996,

    On-line recognition of CO2 exit gas profiles for operational harvesting time of intracellular enzyme products from S-cerevisiae

    , BIOPROCESS ENGINEERING, Vol: 16, Pages: 50-55, ISSN: 0178-515X
  • JOURNAL ARTICLE
    Dehghani M, Bulmer M, Gregory ME, Ison AP, Thornhill NFet al., 1996,

    On-line recognition of CO2 exit gas profiles for operational harvesting time of intracellular enzyme products from S. cerevisiae

    , Bioprocess Engineering, Vol: 16, Pages: 50-55, ISSN: 0178-515X

    This paper concerns the recognition of significant events in the trends from CO 2 exit gas profiles of a S. cerevisiae fermentation. Distinct changes in the on-line monitored variable, CO 2 exit gas concentration, are used to recognise identifiable phases of glucose depletion, biomass formation and the onset of intracellular enzyme production. Process automation for the harvesting of some intracellular enzyme products from S. cerevisiae is considered using on-line recognition of CO 2 exit gas peaks.

  • JOURNAL ARTICLE
    Thornhill NF, Hutchinson RJ, Haughie BT, 1996,

    A probability chart for statistical process analysis, with applications

    , JOURNAL OF PROCESS CONTROL, Vol: 6, Pages: 161-167, ISSN: 0959-1524
  • CONFERENCE PAPER
    Thornhill NF, Sadowski R, Davis JR, Fedenczuk P, Knight MJ, Prichard P, Rothenberg Det al., 1996,

    Practical experiences in refinery control loop performance assessment

    , UKACC International Conference on Control '96, 2-5 September 1996, Pages: 175-180, ISSN: 0537-9989

    The paper presents an example of the application of a control loop performance assessment technique in a refinery setting and diagnoses the causes of oscillations in flow loops.

  • JOURNAL ARTICLE
    DEHGHANI M, BULMER M, GREGORY ME, THORNHILL NFet al., 1995,

    MEASUREMENT VARIABILITY ANALYSIS FOR FERMENTATION PROCESS ASSAYS

    , BIOPROCESS ENGINEERING, Vol: 13, Pages: 239-243, ISSN: 0178-515X
  • JOURNAL ARTICLE
    GREGORY ME, KEAY PJ, DEAN P, BULMER M, THORNHILL NFet al., 1994,

    A VISUAL PROGRAMMING ENVIRONMENT FOR BIOPROCESS CONTROL

    , JOURNAL OF BIOTECHNOLOGY, Vol: 33, Pages: 233-241, ISSN: 0168-1656
  • JOURNAL ARTICLE
    THORNHILL NF, MANELA M, CAMPBELL JA, STONE KMet al., 1994,

    2 METHODS OF SELECTING SMOOTHING SPLINES APPLIED TO FERMENTATION PROCESS DATA

    , AICHE JOURNAL, Vol: 40, Pages: 716-725, ISSN: 0001-1541
  • JOURNAL ARTICLE
    TURNER C, GREGORY ME, THORNHILL NF, 1994,

    CLOSED-LOOP CONTROL OF FED-BATCH CULTURES OF RECOMBINANT ESCHERICHIA-COLI USING ONLINE HPLC

    , BIOTECHNOLOGY AND BIOENGINEERING, Vol: 44, Pages: 819-829, ISSN: 0006-3592
  • JOURNAL ARTICLE
    Turner C, Thornhill NF, Fish NM, 1993,

    A novel method for the on-line analysis of fermentation broth using a sampling device, microcentrifuge and HPLC

    , Biotechnology Techniques, Vol: 7, Pages: 19-24, ISSN: 0951-208X

    This paper describes a novel system for on-line sampling and analysis of whole broth from a fermenter. The system comprises a steam sterilisable sampling device, high speed microcentrifuge and HPLC. We present results characterising the separation efficiency of the microcentrifuge under different conditions, and illustrate the system with glucose and acetate data from an Escherichia coli fermentation using the system. The on-line measurements have been confirmed by off-line analysis. © 1993 Science & Technology Letters.

  • CONFERENCE PAPER
    GREGORY ME, THORNHILL NF, 1992,

    USE OF A GRAPHICAL PROGRAMMING ENVIRONMENT FOR THE RAPID DEVELOPMENT OF CUSTOM SOFTWARE FOR FERMENTATION PROCESS CONTROL

    , 2nd IFAC Symposium on Modeling and Control of Biotechnical Processes 1992/5th International Conference on Computer Applications in Fermentation Technol, Publisher: PERGAMON PRESS LTD, Pages: 231-234, ISSN: 0962-9505
  • CONFERENCE PAPER
    MARSHALL CT, THORNHILL NF, LILLY MD, BUCKLAND BC, FISH NMet al., 1992,

    THE DESIGN AND IMPLEMENTATION OF A COMPARATIVE REASONING TOOL FOR FERMENTATIONS

    , 2nd IFAC Symposium on Modeling and Control of Biotechnical Processes 1992/5th International Conference on Computer Applications in Fermentation Technol, Publisher: PERGAMON PRESS LTD, Pages: 283-286, ISSN: 0962-9505
  • CONFERENCE PAPER
    ROCHE FW, THORNHILL NF, STONE KM, CARLEYSMITH SWet al., 1992,

    FAULT DETECTION AND IDENTIFICATION IN FERMENTERS

    , 2nd IFAC Symposium on Modeling and Control of Biotechnical Processes 1992/5th International Conference on Computer Applications in Fermentation Technol, Publisher: PERGAMON PRESS LTD, Pages: 323-326, ISSN: 0962-9505
  • JOURNAL ARTICLE
    Royce PN, Thornhill NF, 1992,

    Analysis of noise and bias in fermentation oxygen uptake rate data.

    , Biotechnol Bioeng, Vol: 40, Pages: 634-637, ISSN: 0006-3592

    The calculation of many derived fermentation variables such as the respiratory quotient (RQ) and mass transfer coefficient (K(L)a) requires the differences between the molar percentages of oxygen and carbon dioxide in the fermentor inlet and exit gas, called the %OUR and %CER. Noise and bias in %CER data is of order that in the exit gas carbon dioxide analysis. However, the relative amount of noise in the %OUR is one to two orders of magnitude greater than the noise in the raw oxygen analyses because the %OUR is calculated as a small difference between two large quantities. The noise in the %OUR is white with a Gaussian amplitude probability distribution of absolute standard deviation 0.0145. A chi-square filter of the %OUR data is shown to considerably improve the quality of the calculated RQ and K(L)a for a fermentation of Streptomyces clavuligerus.

  • CONFERENCE PAPER
    STONE KM, THORNHILL NF, ROCHE FW, FISH NMet al., 1992,

    A METHOD OF USING OFF-LINE MEASUREMENTS IN AN ON-LINE ESTIMATOR OF BIOMASS CONCENTRATION FOR A PENICILLIN FERMENTATION, AND ITS EFFECTS ON THE QUALITY OF THE ESTIMATES

    , 2nd IFAC Symposium on Modeling and Control of Biotechnical Processes 1992/5th International Conference on Computer Applications in Fermentation Technol, Publisher: PERGAMON PRESS LTD, Pages: 101-106, ISSN: 0962-9505
  • JOURNAL ARTICLE
    Stone KM, Roche FW, Thornhill NF, 1992,

    DRY WEIGHT MEASUREMENT OF MICROBIAL BIOMASS AND MEASUREMENT VARIABILITY ANALYSIS

    , BIOTECHNOLOGY TECHNIQUES, Vol: 6, Pages: 207-212, ISSN: 0951-208X
  • CONFERENCE PAPER
    TURNER C, THORNHILL NF, FISH NM, 1992,

    ON-LINE SAMPLING AND ANALYSIS OF FERMENTATION BROTH USING A NOVEL SAMPLING DEVICE, MICROCENTRIFUGE AND HPLC

    , 2nd IFAC Symposium on Modeling and Control of Biotechnical Processes 1992/5th International Conference on Computer Applications in Fermentation Technol, Publisher: PERGAMON PRESS LTD, Pages: 339-342, ISSN: 0962-9505
  • JOURNAL ARTICLE
    ROYCE PNC, THORNHILL NF, 1991,

    ESTIMATION OF DISSOLVED CARBON-DIOXIDE CONCENTRATIONS IN AEROBIC FERMENTATIONS

    , AICHE JOURNAL, Vol: 37, Pages: 1680-1686, ISSN: 0001-1541
  • JOURNAL ARTICLE
    FISH N, THORNHILL N, 1988,

    MONITORING AND CONTROL OF FERMENTATION

    , CHEMICAL ENGINEER-LONDON, Pages: 31-&, ISSN: 0302-0797
  • JOURNAL ARTICLE
    Vickery JC, Anderson JC, Husband TM, Kavina Y, Thornhill NFet al., 1983,

    DEBONING BACON BACKS.

    , IEE Colloquium (Digest), ISSN: 0963-3308

    The project is to investigate the possibilities for automatically removing the rib and residual backbones from bacon backs, prior to vehicle in practical trials but it is envisaged that a successful deboner would ultimately use a purpose built machine. The work is being carried out with the co-operation of Glengrove Ltd, a Sussex meat processing Company. The research is split into four main areas - Sensing of bone; Method of separating bones from meat; Handling presentation and gripping the meat; Software for sensor signal interpretation and control of robot and co-operating hardware.

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