Imperial College London
Alternate

ProfessorAlexBlakemore

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 2156a.blakemore

 
 
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Location

 

Commonwealth Building, 6N2BHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fairbrother:2007:10.1359/jbmr.070114,
author = {Fairbrother, UL and Tanko, LB and Walley, AJ and Christiansen, C and Froguel, P and Blakemore, AI},
doi = {10.1359/jbmr.070114},
journal = {J Bone Miner Res},
pages = {544--550},
title = {Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women},
url = {http://dx.doi.org/10.1359/jbmr.070114},
volume = {22},
year = {2007}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Leptin is emerging as a key regulator of bone remodeling. In a population-based study of 1306 postmenopausal Danish women, nonsynonymous LEPR SNPs were associated with risk of adiposity, BMD, and vertebral fracture. Smoking exacerbates this LEPR-associated fracture risk. INTRODUCTION: Nonsynonymous single nucleotide polymorphisms (SNPs) in the human LEPR gene have been associated with adiposity in a number of studies, but there have been no large-scale studies of their implications for BMD and osteoporotic fracture risk in postmenopausal women. MATERIALS AND METHODS: We carried out a population-based study of 1430 women. Three well-known nonsynonymous leptin receptor (LEPR) SNPs (Lys109Arg, Gln223Arg, and Lys656Asn) were genotyped for qualitative and quantitative association analysis. Phenotype characteristics of main interest were DXA measures of body fat and lean tissue mass, BMD, and radiographic vertebral fractures. RESULTS: Gln223Arg associated with risk of vertebral fracture (overall OR = 1.76; OR in smokers = 2.31; p = 0.0004), in addition to BMD of the femoral neck and total hip (p = 0.036 and 0.008, respectively). Heterozygote carriers showed lower BMD at both sites. Gln223Arg was also associated with adiposity (p = 0.001 for total fat mass). For adiposity, the at-risk allele was G (resulting in an arginine at position 223). CONCLUSIONS: Variation in LEPR seemed to contribute to the variation in BMD and fracture risk in Danish postmenopausal women; the heterozygous genotype was associated with increased risk of manifest osteoporosis. Further studies are needed to replicate these data and to clarify the mechanisms involved.
AU  - Fairbrother,UL
AU  - Tanko,LB
AU  - Walley,AJ
AU  - Christiansen,C
AU  - Froguel,P
AU  - Blakemore,AI
DO  - 10.1359/jbmr.070114
EP  - 550
PY  - 2007///
SN  - 0884-0431
SP  - 544
TI  - Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women
T2  - J Bone Miner Res
UR  - http://dx.doi.org/10.1359/jbmr.070114
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17243864
VL  - 22
ER  -
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