Imperial College London
Alternate

ProfessorAlexBlakemore

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 2156a.blakemore

 
 
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Location

 

Commonwealth Building, 6N2BHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Quinton:2001,
author = {Quinton, ND and Lee, AJ and Ross, RJ and Eastell, R and Blakemore, AI},
journal = {Hum Genet},
pages = {233--236},
title = {A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11354636},
volume = {108},
year = {2001}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The human leptin (obese) receptor gene contains a number of single nucleotide polymorphisms, including GLN223ARG, which changes an amino acid on the extracellular region common to all isoforms of the receptor. Here, we demonstrate that, in postmenopausal Caucasian women, genotypes at that locus are associated with differences in body mass index (BMI), fat mass and serum leptin levels. Measurement of serum leptin-binding activity indicates that this may reflect changed receptor function associated with genotype. These observations indicate that functional variations in the leptin receptor gene are important factors in the regulation of adiposity and BMI.
AU  - Quinton,ND
AU  - Lee,AJ
AU  - Ross,RJ
AU  - Eastell,R
AU  - Blakemore,AI
EP  - 236
PY  - 2001///
SN  - 0340-6717
SP  - 233
TI  - A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women
T2  - Hum Genet
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11354636
VL  - 108
ER  -
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