Imperial College London
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ProfessorAdnanCustovic

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Allergy
 
 
 
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a.custovic CV

 
 
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Location

 

220Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Tang:2017:10.1101/237073,
author = {Tang, HHF and Teo, SM and Belgrave, DCM and Evans, M and Jackson, D and Brozynska, M and Kusel, MMH and Johnston, S and Gern, J and Lemanske, R and Simpson, A and Custovic, A and Sly, P and Holt, P and Holt, K and Inouye, M},
doi = {10.1101/237073},
publisher = {bioRxiv},
title = {Non-parametric mixture models identify trajectories of childhood immune development relevant to asthma and allergy},
url = {http://dx.doi.org/10.1101/237073},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterogeneous and do not always result in asthma. Similarly, not all atopic individuals develop wheeze, and vice versa. The reasons for these differences are unclear. Using unsupervised model-based cluster analysis, we identified latent clusters within a prospective birth cohort with deep immunological and respiratory phenotyping. We characterised each cluster in terms of immunological profile and disease risk, and replicated our results in external cohorts from the UK and USA. We discovered three distinct trajectories, one of which is a high-risk "atopic" cluster with increased propensity for allergic diseases throughout childhood. Atopy contributes varyingly to later wheeze depending on cluster membership. Our findings demonstrate the utility of unsupervised analysis in elucidating heterogeneity in asthma pathogenesis and provide a foundation for improving management and prevention of childhood asthma.
AU  - Tang,HHF
AU  - Teo,SM
AU  - Belgrave,DCM
AU  - Evans,M
AU  - Jackson,D
AU  - Brozynska,M
AU  - Kusel,MMH
AU  - Johnston,S
AU  - Gern,J
AU  - Lemanske,R
AU  - Simpson,A
AU  - Custovic,A
AU  - Sly,P
AU  - Holt,P
AU  - Holt,K
AU  - Inouye,M
DO  - 10.1101/237073
PB  - bioRxiv
PY  - 2017///
TI  - Non-parametric mixture models identify trajectories of childhood immune development relevant to asthma and allergy
UR  - http://dx.doi.org/10.1101/237073
UR  - https://www.biorxiv.org/content/early/2017/12/20/237073
UR  - http://hdl.handle.net/10044/1/63017
ER  -
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