Imperial College London
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ProfessorAdnanCustovic

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Allergy
 
 
 
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a.custovic CV

 
 
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Location

 

220Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Howard:2018:10.1016/j.jaci.2017.11.064,
author = {Howard, R and Belgrave, D and Papastamoulis, P and Simpson, A and Rattray, M and Custovic, A},
doi = {10.1016/j.jaci.2017.11.064},
journal = {Journal of Allergy and Clinical Immunology},
pages = {1322--1330},
title = {Evolution of IgE responses to multiple allergen components throughout childhood},
url = {http://dx.doi.org/10.1016/j.jaci.2017.11.064},
volume = {142},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: There is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins (components) from multiple sources. OBJECTIVE: To investigate temporal patterns of component-specific IgE responses from infancy to adolescence, and their relationship with allergic diseases. METHODS: In a population-based birth cohort, we measured IgE to 112 components at 6 follow-ups during childhood. We used a Bayesian method to discover cross-sectional sensitization patterns and their longitudinal trajectories, and related these patterns to asthma and rhinitis in adolescence. RESULTS: We identified one sensitization cluster at age one, 3 at age three, 4 at ages five and eight, 5 at age 11, and six at age 16 years. "Broad" cluster was the only cluster present at every follow-up, comprising of components from multiple sources. "Dust mite" cluster formed at age three and remained unchanged to adolescence. At age three, a single-component "Grass" cluster emerged, which at age five absorbed additional grass components and Fel d 1 to form the "Grass/cat" cluster. Two new clusters formed at age 11: "Cat" cluster and "PR-10/profilin" (which divided at age 16 into "PR-10" and "Profilin"). The strongest contemporaneous associate of asthma at age 16 years was sensitization to "Dust mite" cluster (OR [95% CI]: 2.6 [1.2-6.1], P<0.05), but the strongest early-life predictor of subsequent asthma was sensitization to "Grass/cat" cluster (3.5 [1.6-7.4], P<0.01). CONCLUSIONS: We describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, which may facilitate development of better diagnostic and prognostic biomarkers for allergic diseases.
AU  - Howard,R
AU  - Belgrave,D
AU  - Papastamoulis,P
AU  - Simpson,A
AU  - Rattray,M
AU  - Custovic,A
DO  - 10.1016/j.jaci.2017.11.064
EP  - 1330
PY  - 2018///
SN  - 0091-6749
SP  - 1322
TI  - Evolution of IgE responses to multiple allergen components throughout childhood
T2  - Journal of Allergy and Clinical Immunology
UR  - http://dx.doi.org/10.1016/j.jaci.2017.11.064
UR  - http://hdl.handle.net/10044/1/57052
VL  - 142
ER  -
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