Imperial College London
Alternate

Professor Amin Hajitou

Faculty of Medicine, Department of Brain Sciences

Professor of Targeted Therapeutics
 
 
 
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Contact

 

+44 (0)20 7594 6546a.hajitou Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chira:2017:10.1016/j.omtn.2017.04.001,
author = {Chira, S and Gulei, D and Hajitou, A and Zimta, A-A and Cordelier, P and Berindan-Neagoe, I},
doi = {10.1016/j.omtn.2017.04.001},
journal = {Molecular Therapy : Nucleic Acids},
pages = {211--222},
title = {CRISPR/Cas9: transcending the reality of genome editing},
url = {http://dx.doi.org/10.1016/j.omtn.2017.04.001},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - With the expansion of the microbiology field of research, a newgenome editing tool arises from the biology of bacteria thatholds the promise of achieving precise modifications in thegenome with a simplicity and versatility that surpasses previousgenome editing methods. This new technique, commonlynamed CRISPR/Cas9, led to a rapid expansion of thebiomedical field; more specifically, cancer characterizationand modeling have benefitted greatly from the genome editingcapabilities of CRISPR/Cas9. In this paper, we briefly summarizerecent improvements in CRISPR/Cas9 design meant toovercome the limitations that have arisen from the nuclease activityof Cas9 and the influence of this technology in cancerresearch. In addition, we present challenges that might impedethe clinical applicability of CRISPR/Cas9 for cancer therapyand highlight future directions for designing CRISPR/Cas9 deliverysystems that might prove useful for cancer therapeutics.
AU  - Chira,S
AU  - Gulei,D
AU  - Hajitou,A
AU  - Zimta,A-A
AU  - Cordelier,P
AU  - Berindan-Neagoe,I
DO  - 10.1016/j.omtn.2017.04.001
EP  - 222
PY  - 2017///
SN  - 2162-2531
SP  - 211
TI  - CRISPR/Cas9: transcending the reality of genome editing
T2  - Molecular Therapy : Nucleic Acids
UR  - http://dx.doi.org/10.1016/j.omtn.2017.04.001
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401233700020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/58015
VL  - 7
ER  -
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