Imperial College London
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MrAlexLiddle

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Orthopaedics
 
 
 
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Contact

 

a.liddle Website

 
 
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Assistant

 

Miss Colinette Hazel +44 (0)20 7594 2725

 
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Location

 

203Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hexter:2018:10.1302/0301-620X.100B2.BJJ-2017-0575.R1,
author = {Hexter, AT and Hislop, SM and Blunn, GW and Liddle, AD},
doi = {10.1302/0301-620X.100B2.BJJ-2017-0575.R1},
journal = {Bone and Joint Journal},
pages = {134--142},
title = {The effect of bearing surface on risk of periprosthetic joint infection in total hip arthroplasty: A systematic review and meta-analysis},
url = {http://dx.doi.org/10.1302/0301-620X.100B2.BJJ-2017-0575.R1},
volume = {100B},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimsPeriprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty (THA). Different bearing surface materials have different surface properties and it has been suggested that the choice of bearing surface may influence the risk of PJI after THA. The objective of this meta-analysis was to compare the rate of PJI between metal-on-polyethylene (MoP), ceramic-on-polyethylene (CoP), and ceramic-on-ceramic (CoC) bearings.Patients and MethodsElectronic databases (Medline, Embase, Cochrane library, Web of Science, and Cumulative Index of Nursing and Allied Health Literature) were searched for comparative randomized and observational studies that reported the incidence of PJI for different bearing surfaces. Two investigators independently reviewed studies for eligibility, evaluated risk of bias, and performed data extraction. Meta-analysis was performed using the Mantel–Haenzel method and random-effects model in accordance with methods of the Cochrane group.ResultsOur search strategy revealed 2272 studies, of which 17 met the inclusion criteria and were analyzed. These comprised 11 randomized controlled trials and six observational studies. The overall quality of included studies was high but the observational studies were at high risk of bias due to inadequate adjustment for confounding factors. The overall cumulative incidence of PJI across all studies was 0.78% (1514/193 378). For each bearing combination, the overall incidence was as follows: MoP 0.85% (1353/158 430); CoP 0.38% (67/17 489); and CoC 0.53% (94/17 459). The meta-analysis showed no significant difference between the three bearing combinations in terms of risk of PJI.ConclusionOn the basis of the clinical studies available, there is no evidence that bearing choice influences the risk of PJI. Future research, including basic science studies and large, adequately controlled registry studies, may be helpful in determining whether implant materials play a role in determining the ri
AU  - Hexter,AT
AU  - Hislop,SM
AU  - Blunn,GW
AU  - Liddle,AD
DO  - 10.1302/0301-620X.100B2.BJJ-2017-0575.R1
EP  - 142
PY  - 2018///
SN  - 2049-4394
SP  - 134
TI  - The effect of bearing surface on risk of periprosthetic joint infection in total hip arthroplasty: A systematic review and meta-analysis
T2  - Bone and Joint Journal
UR  - http://dx.doi.org/10.1302/0301-620X.100B2.BJJ-2017-0575.R1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000425967900003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69902
VL  - 100B
ER  -
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