Imperial College London
Alternate

ProfessorAlexandraPorter

Faculty of Engineering, Department of Materials

Professor of Bio-imaging and Analysis
 
 
 
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Contact

 

+44 (0)20 7594 9691a.porter

 
 
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Location

 

B341 Royal School of MinesRoyal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Naruphontjirakul:2016:10.1515/bglass-2016-0009,
author = {Naruphontjirakul, P and Greasley, SL and Chen, S and Porter, AE and Jones, JR},
doi = {10.1515/bglass-2016-0009},
pages = {72--81},
title = {Monodispersed strontium containing bioactive glass nanoparticles and MC3T3-E1 cellular response},
url = {http://dx.doi.org/10.1515/bglass-2016-0009},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Non-porous monodispersed strontium containing bioactive glass (Si2O-CaO-SrO) nanoparticles (SrBGNPs), were synthesised using a modified Stöber process. Silica nanoparticles (Si-NPs) with diameters 90 10 nm were produced through hydrolysis and polycondensation reactions of the silicon alkoxide precursor, tetraethyl orthosilicate (TEOS), prior to the incorporation of cations; calcium (Ca) and strontium (Sr), into the silica networks through heat treatment (calcination). Sr was substituted for Ca on a mole basis from non- (0SrBGNPs) to full-substitution (100SrBGNPs) in order to increase the amount of network modifiers in the Si-NPs. The different ratios of Si: Ca; 1:1.3 and 1:8.0, presented various elemental compositions (i.e. 77-92 mol% of SiO2). The effect of Si: Ca/Sr ratio on particle size, morphology and dispersity was evaluated, as well as the in vitro cell viability effect of SrBGNPs and their dissolution products on pre-osteoblast cell line, MC3T3-E1. Sr incorporation did not affect particle size or dispersity. For 1:1.3 ratio, SrBGNPs caused no toxic effects on the cells and dissolution products of 75- and 100-SrBGNPs showed great potential to promote MC3T3-E1 activity.
AU  - Naruphontjirakul,P
AU  - Greasley,SL
AU  - Chen,S
AU  - Porter,AE
AU  - Jones,JR
DO  - 10.1515/bglass-2016-0009
EP  - 81
PY  - 2016///
SP  - 72
TI  - Monodispersed strontium containing bioactive glass nanoparticles and MC3T3-E1 cellular response
UR  - http://dx.doi.org/10.1515/bglass-2016-0009
ER  -
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