Imperial College London
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Professor Alina Rodriguez, CPsychol

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0941a.rodriguez

 
 
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Location

 

168Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Wiklund:2018:10.1101/428896,
author = {Wiklund, P and Karhunen, V and Richmond, RC and Rodriguez, A and De, Silva M and Wielscher, M and Rezwan, FI and Richardson, TG and Veijola, J and Heinz-Herzig, K and Holloway, JW and Relton, CL and Sebert, S and Järvelin, M-R},
doi = {10.1101/428896},
title = {DNA methylation links prenatal smoking exposure to later life health outcomes in offspring},
url = {http://dx.doi.org/10.1101/428896},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:p>Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. To test this, we examined the association of prenatal maternal smoking with DNA methylation in 2,821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess, whether methylation markers have causal effects on disease outcomes in the offspring. We identify 69 differentially methylated CpGs in 36 genomic regions (P < 1×10<jats:sup>−7</jats:sup>), and show that DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.</jats:p>
AU  - Wiklund,P
AU  - Karhunen,V
AU  - Richmond,RC
AU  - Rodriguez,A
AU  - De,Silva M
AU  - Wielscher,M
AU  - Rezwan,FI
AU  - Richardson,TG
AU  - Veijola,J
AU  - Heinz-Herzig,K
AU  - Holloway,JW
AU  - Relton,CL
AU  - Sebert,S
AU  - Järvelin,M-R
DO  - 10.1101/428896
PY  - 2018///
TI  - DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
UR  - http://dx.doi.org/10.1101/428896
ER  -
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