Imperial College London
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Dr Andrew D. Scott

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2937a.scott07

 
 
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Location

 

Cardiovascular MR UnitRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Roehl:2024:10.1007/s10334-023-01141-8,
author = {Roehl, M and Conway, M and Ghonim, S and Ferreira, P and Nielles-Vallespin, S and Babu-Narayan, S and Pennell, D and Gatehouse, P and Scott, A},
doi = {10.1007/s10334-023-01141-8},
journal = {Magnetic Resonance Materials in Physics, Biology and Medicine},
pages = {295--305},
title = {STEAM-SASHA: a novel approach for blood- and fat-suppressed native T1 measurement in the right ventricular myocardium},
url = {http://dx.doi.org/10.1007/s10334-023-01141-8},
volume = {37},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective:The excellent blood and fat suppression of stimulated echo acquisition mode (STEAM) can be combined with saturation recovery single-shot acquisition (SASHA) in a novel STEAM-SASHA sequence for right ventricular (RV) native T1 mapping.Materials and methods:STEAM-SASHA splits magnetization preparation over two cardiac cycles, nulling blood signal and allowing fat signal to decay. Breath-hold T1 mapping was performed in a T1 phantom and twice in 10 volunteers using STEAM-SASHA and a modified Look-Locker sequence at peak systole at 3T. T1 was measured in 3 RV regions, the septum and left ventricle (LV).Results:In phantoms, MOLLI under-estimated while STEAM-SASHA over-estimated T1, on average by 3.0% and 7.0% respectively, although at typical 3T myocardial T1 (T1 > 1200 ms) STEAM-SASHA was more accurate. In volunteers, T1 was higher using STEAM-SASHA than MOLLI in the LV and septum (p = 0.03, p = 0.006, respectively), but lower in RV regions (p > 0.05). Inter-study, inter-observer and intra-observer coefficients of variation in all regions were < 15%. Blood suppression was excellent with STEAM-SASHA and noise floor effects were minimal.Discussion:STEAM-SASHA provides accurate and reproducible T1 in the RV with excellent blood and fat suppression. STEAM-SASHA has potential to provide new insights into pathological changes in the RV in future studies.
AU  - Roehl,M
AU  - Conway,M
AU  - Ghonim,S
AU  - Ferreira,P
AU  - Nielles-Vallespin,S
AU  - Babu-Narayan,S
AU  - Pennell,D
AU  - Gatehouse,P
AU  - Scott,A
DO  - 10.1007/s10334-023-01141-8
EP  - 305
PY  - 2024///
SN  - 0968-5243
SP  - 295
TI  - STEAM-SASHA: a novel approach for blood- and fat-suppressed native T1 measurement in the right ventricular myocardium
T2  - Magnetic Resonance Materials in Physics, Biology and Medicine
UR  - http://dx.doi.org/10.1007/s10334-023-01141-8
UR  - https://link.springer.com/article/10.1007/s10334-023-01141-8#article-info
UR  - http://hdl.handle.net/10044/1/108889
VL  - 37
ER  -
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