Imperial College London
Professor Athol Wells

ProfessorAtholWells

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

a.wells

 
 
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Location

 

Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

565 results found

Patel A, Basu T, Siegert R, Keir G, Larkin G, Wells A, Higginson I, Creamer JD, Birring Set al., 2012, The assessment of health-related quality of life in sarcoidosis using a novel sarcoidosis questionnaire, 92nd Annual Meeting of the British-Association-of-Dermatologists, Publisher: WILEY-BLACKWELL, Pages: 52-52, ISSN: 0007-0963

Conference paper

Corte TJ, Wort SJ, MacDonald PS, Edey A, Hansell DM, Renzoni E, Maher TM, Nicholson AG, Bandula S, Bresser P, Wells AUet al., 2012, Pulmonary function vascular index predicts prognosis in idiopathic interstitial pneumonia, RESPIROLOGY, Vol: 17, Pages: 674-680, ISSN: 1323-7799

Journal article

Betteridge ZE, Woodhead F, Bunn C, Denton CP, Abraham D, Desai S, du Bois R, Wells A, McHugh Net al., 2012, ANTI-EIF2 IS ASSOCIATED WITH INTERSTITIAL LUNG DISEASE IN PATIENTS WITH SYSTEMIC SCLEROSIS, Annual Meeting of the British-Society-for-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 34-35, ISSN: 1462-0324

Conference paper

Wijesekera NT, Walsh SL, Wells AU, Hansell DMet al., 2012, Image Quality of Computed Tomographic Pulmonary Angiography for Suspected Pulmonary Embolus in Patients With Diffuse Interstitial Lung Disease, JOURNAL OF THORACIC IMAGING, Vol: 27, Pages: 156-163, ISSN: 0883-5993

Journal article

Wells AU, Behr J, Costabel U, Cottin V, Poletti Vet al., 2012, Triple therapy in idiopathic pulmonary fibrosis: an alarming press release, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 805-806, ISSN: 0903-1936

Journal article

Sozio F, Rossi A, Weber E, Abraham DJ, Nicholson AG, Wells AU, Renzoni EA, Sestini Pet al., 2012, Morphometric analysis of intralobular, interlobular and pleural lymphatics in normal human lung, JOURNAL OF ANATOMY, Vol: 220, Pages: 396-404, ISSN: 0021-8782

Journal article

Bajwah S, Higginson IJ, Ross JR, Wells AU, Birring SS, Patel A, Riley Jet al., 2012, Specialist Palliative Care is More Than Drugs: A Retrospective Study of ILD Patients, LUNG, Vol: 190, Pages: 215-220, ISSN: 0341-2040

Journal article

Margaritopoulos GA, Romagnoli M, Poletti V, Siafakas NM, Wells AU, Antoniou KMet al., 2012, Recent advances in the pathogenesis and clinical evaluation of pulmonary fibrosis., Eur Respir Rev, Vol: 21, Pages: 48-56

Interstitial lung diseases (ILDs) are a group of heterogeneous disorders, either idiopathic or associated with injurious or inflammatory causes, in which the major site of damage is the lung interstitium. For a long time, knowledge regarding pathogenesis was trivial and there were difficulties in diagnosing and subsequently treating these diseases. During the past decade, however, there has been an impressive development in the field of ILDs. Idiopathic pulmonary fibrosis, the most common and fatal form of ILD, was initially believed to be due to an inflammatory response to unknown lung injury, whereas nowadays it is believed to be the result of multiple injuries at different sites of the lung followed by aberrant repair. The integration of clinical, radiological and histological data, namely a multidisciplinary team (MDT) approach, has provided grounds for a more accurate diagnosis of ILDs, and helped the identification of different entities and development of different therapeutic approaches. However, because of the complexity of ILDs, even this approach may fail to establish a confident diagnosis. How should the clinician behave in this case and what are the pitfalls of the MDT approach? In addition, since diagnosis is the major predictor of prognosis, are there any other tools available to predict prognosis?

Journal article

Corte TJ, Copley SJ, Desai SR, Zappala CJ, Hansell DM, Nicholson AG, Colby TV, Renzoni E, Maher TM, Wells AUet al., 2012, Significance of connective tissue disease features in idiopathic interstitial pneumonia, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 661-668, ISSN: 0903-1936

Journal article

Thillai M, Potiphar L, Eberhardt C, Pareek M, Dhawan R, Kon OM, Wickremasinghe M, Wells A, Mitchell D, Lalvani Aet al., 2012, Obstructive lung function in sarcoidosis may be missed, especially in older white patients, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 775-777, ISSN: 0903-1936

Journal article

Zappala C, Wells A, 2012, Aetiology and clinical phenotype still seem distant in sarcoidosis, RESPIROLOGY, Vol: 17, Pages: 199-200, ISSN: 1323-7799

Journal article

Rowan C, Hansell DM, Renzoni E, Maher TM, Wells AU, Polkey MI, Rehal PK, Ibrahim WH, Kwong GNM, Colby TV, Pistolesi M, Bigazzi F, Comin CE, Nicholson AGet al., 2012, Diffuse Cystic Lung Disease of Unexplained Cause With Coexistent Small Airway Disease: A Possible Causal Relationship?, AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Vol: 36, Pages: 228-234, ISSN: 0147-5185

Journal article

Stock C, Sato H, Fonseca C, Lindahl GE, Maher TM, Wells AU, Denton CP, Abraham DJ, Renzoni EAet al., 2012, A MUC5B PROMOTER POLYMORPHISM AND PULMONARY FIBROSIS IN SSc, 2nd Systemic Sclerosis World Congress, Publisher: OXFORD UNIV PRESS, Pages: 30-30, ISSN: 1462-0324

Conference paper

Margaritopoulos GA, Wells AU, 2012, The role of transbronchial biopsy in the diagnosis of diffuse parenchymal lung diseases: <i>Con</i>, REVISTA PORTUGUESA DE PNEUMOLOGIA, Vol: 18, Pages: 61-63, ISSN: 0873-2159

Journal article

Corte TJ, Wort SJ, Talbot S, Macdonald PM, Hansell DM, Polkey M, Renzoni E, Maher TM, Nicholson AG, Wells AUet al., 2012, ELEVATED NOCTURNAL DESATURATION INDEX PREDICTS MORTALITY IN INTERSTITIAL LUNG DISEASE, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Vol: 29, Pages: 41-50, ISSN: 1124-0490

Journal article

Thillai M, Eberhardt C, Lewin AM, Potiphar L, Hingley-Wilson S, Sridhar S, Macintyre J, Kon OM, Wickremasinghe M, Wells A, Weeks ME, Mitchell D, Lalvani Aet al., 2012, Sarcoidosis and tuberculosis cytokine profiles: indistinguishable in bronchoalveolar lavage but different in blood, PLoS One, Vol: 7, ISSN: 1932-6203

BACKGROUND: The clinical, radiological and pathological similarities between sarcoidosis and tuberculosis can make disease differentiation challenging. A complicating factor is that some cases of sarcoidosis may be initiated by mycobacteria. We hypothesised that immunological profiling might provide insight into a possible relationship between the diseases or allow us to distinguish between them. METHODS: We analysed bronchoalveolar lavage (BAL) fluid in sarcoidosis (n = 18), tuberculosis (n = 12) and healthy volunteers (n = 16). We further investigated serum samples in the same groups; sarcoidosis (n = 40), tuberculosis (n = 15) and healthy volunteers (n = 40). A cross-sectional analysis of multiple cytokine profiles was performed and data used to discriminate between samples. RESULTS: We found that BAL profiles were indistinguishable between both diseases and significantly different from healthy volunteers. In sera, tuberculosis patients had significantly lower levels of the Th2 cytokine interleukin-4 (IL-4) than those with sarcoidosis (p = 0.004). Additional serum differences allowed us to create a linear regression model for disease differentiation (within-sample accuracy 91%, cross-validation accuracy 73%). CONCLUSIONS: These data warrant replication in independent cohorts to further develop and validate a serum cytokine signature that may be able to distinguish sarcoidosis from tuberculosis. Systemic Th2 cytokine differences between sarcoidosis and tuberculosis may also underly different disease outcomes to similar respiratory stimuli.

Journal article

Baughman RP, Drent M, Culver DA, Grutters JC, Handa T, Humbert M, Judson MA, Lower EE, Mana J, Pereira CA, Prasse A, Sulica R, Valyere D, Vucinic V, Wells AUet al., 2012, ENDPOINTS FOR CLINICAL TRIALS OF SARCOIDOSIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Vol: 29, Pages: 90-98, ISSN: 1124-0490

Journal article

Patel, Siegert, Creamer, Larkin, Maher, Renzoni, Wells, Higginson, Birringet al., 2012, The development and validation of the King'sSarcoidosis Questionnaire for the assessment of health status., Thorax

Journal article

du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, King TE, Lancaster L, Noble PW, Sahn SA, Thomeer M, Valeyre D, Wells AUet al., 2011, Forced Vital Capacity in Patients with Idiopathic Pulmonary Fibrosis Test Properties and Minimal Clinically Important Difference, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 184, Pages: 1382-1389, ISSN: 1073-449X

Journal article

Bajwah S, Koffman J, Higginson IJ, Ross JR, Wells AU, Birring SS, Patel A, Riley Jet al., 2011, THE NEEDS AND EXPERIENCES OF PROGRESSIVE IDIOPATHIC FIBROTIC INTERSTITIAL LUNG DISEASE PATIENTS, INFORMAL CAREGIVERS AND HEALTH PROFESSIONALS: A QUALITATIVE STUDY, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A103-A103, ISSN: 0040-6376

Conference paper

Keir GJ, Wells AU, Wort SJ, 2011, THE USE OF SILDENAFIL TO TREAT PULMONARY HYPERTENSION ASSOCIATED WITH SARCOIDOSIS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A68-A68, ISSN: 0040-6376

Conference paper

Sinha A, Lee KK, Patel AS, Rafferty GF, Wells AU, Birring SSet al., 2011, THE ASSOCIATION BETWEEN COUGH REFLEX SENSITIVITY AND SERUM ACE LEVEL IN PATIENTS WITH SARCOIDOSIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A62-A63, ISSN: 0040-6376

Conference paper

Patel AS, Siegert R, Creamer D, Larkin G, Gray B, Wells AU, Higginson IJ, Birring SSet al., 2011, THE ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN SARCOIDOSIS WITH THE KING'S SARCOIDOSIS QUESTIONNAIRE (KSQ), Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A102-A103, ISSN: 0040-6376

Conference paper

Renzoni EA, Weber E, Sozio F, Rossi A, Wells AUet al., 2011, LYMPHATIC VESSEL DISTRIBUTION IN FIBROTIC LUNG DISEASES, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A52-A53, ISSN: 0040-6376

Conference paper

Patel AS, Siegert R, Brignall K, Keir G, Bajwah S, Desai SR, Wells AU, Higginson IJ, Birring SSet al., 2011, THE ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN INTERSTITIAL LUNG DISEASE WITH THE KING'S BRIEF INTERSTITIAL LUNG DISEASE QUESTIONNAIRE (K-BILD), Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A61-A61, ISSN: 0040-6376

Conference paper

Schreiber BE, Valerio CJ, Keir GJ, Handler C, Wells AU, Denton CP, Coghlan JGet al., 2011, Improving the Detection of Pulmonary Hypertension in Systemic Sclerosis Using Pulmonary Function Tests, ARTHRITIS AND RHEUMATISM, Vol: 63, Pages: 3531-3539, ISSN: 0004-3591

Journal article

Visca D, Montgomery A, de Lauretis A, Sestini P, Soteriou H, Maher TM, Wells AU, Renzoni EAet al., 2011, Ambulatory oxygen in interstitial lung disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 38, Pages: 987-990, ISSN: 0903-1936

Journal article

Zappala CJ, Desai SR, Copley SJ, Spagnolo P, Cramer D, Sen D, Alam SM, du Bois RM, Hansell DM, Wells AUet al., 2011, OPTIMAL SCORING OF SERIAL CHANGE ON CHEST RADIOGRAPHY IN SARCOIDOSIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Vol: 28, Pages: 130-138, ISSN: 1124-0490

Journal article

Schreiber BE, Valerio C, Keir G, Handler C, Wells AU, Denton CP, Coghlan JGet al., 2011, Diffusion of Carbon Monoxide Predicts Survival in Systemic Sclerosis Patients with Pulmonary Hypertension and Interstitial Lung Disease, 75th Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) / 46th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals (ARHP), Publisher: WILEY, Pages: S968-S968, ISSN: 0004-3591

Conference paper

Wells A, 2011, CT Detection of Pulmonary Hypertension in Interstitial Lung Disease: The Glass Is Half Full, RADIOLOGY, Vol: 260, Pages: 628-631, ISSN: 0033-8419

Journal article

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