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@article{Fonseca-Nunes:2015:10.1002/ijc.29669,
author = {Fonseca-Nunes, A and Agudo, A and Aranda, N and Arija, V and Cross, AJ and Molina, E and Jose, Sanchez M and Bueno-de-Mesquita, HBA and Siersema, P and Weiderpass, E and Krogh, V and Mattiello, A and Tumino, R and Saieva, C and Naccarati, A and Ohlsson, B and Sjoberg, K and Boutron-Ruault, M-C and Cadeau, C and Fagherazzi, G and Boeing, H and Steffen, A and Kuehn, T and Katzke, V and Tjonneland, A and Olsen, A and Khaw, K-T and Wareham, N and Key, T and Lu, Y and Riboli, E and Peeters, PH and Gavrila, D and Dorronsoro, M and Ramon, Quiros J and Barricarte, A and Jenab, M and Zamora-Ros, R and Freisling, H and Trichopoulou, A and Lagiou, P and Bamia, C and Jakszyn, P},
doi = {10.1002/ijc.29669},
journal = {International Journal of Cancer},
pages = {2904--2914},
title = {Body iron status and gastric cancer risk in the EURGAST study},
url = {http://dx.doi.org/10.1002/ijc.29669},
volume = {137},
year = {2015}
}

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TY  - JOUR
AB  - Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case–control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 = 0.80, 95% CI = 0.72–0.88; OR10%increment = 0.87, 95% CI = 0.78–0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity = 0.04 and TS had a p for heterogeneity = 0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl = 1.13, 95% CI = 1.02–1.2) and also with noncardia gastric cancer (p for heterogeneity = 0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis.
AU  - Fonseca-Nunes,A
AU  - Agudo,A
AU  - Aranda,N
AU  - Arija,V
AU  - Cross,AJ
AU  - Molina,E
AU  - Jose,Sanchez M
AU  - Bueno-de-Mesquita,HBA
AU  - Siersema,P
AU  - Weiderpass,E
AU  - Krogh,V
AU  - Mattiello,A
AU  - Tumino,R
AU  - Saieva,C
AU  - Naccarati,A
AU  - Ohlsson,B
AU  - Sjoberg,K
AU  - Boutron-Ruault,M-C
AU  - Cadeau,C
AU  - Fagherazzi,G
AU  - Boeing,H
AU  - Steffen,A
AU  - Kuehn,T
AU  - Katzke,V
AU  - Tjonneland,A
AU  - Olsen,A
AU  - Khaw,K-T
AU  - Wareham,N
AU  - Key,T
AU  - Lu,Y
AU  - Riboli,E
AU  - Peeters,PH
AU  - Gavrila,D
AU  - Dorronsoro,M
AU  - Ramon,Quiros J
AU  - Barricarte,A
AU  - Jenab,M
AU  - Zamora-Ros,R
AU  - Freisling,H
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Bamia,C
AU  - Jakszyn,P
DO  - 10.1002/ijc.29669
EP  - 2914
PY  - 2015///
SN  - 1097-0215
SP  - 2904
TI  - Body iron status and gastric cancer risk in the EURGAST study
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.29669
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362843300017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/44860
VL  - 137
ER  -

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