Publications
664 results found
Marx A, Stroebel P, Badve SS, et al., 2014, ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting, JOURNAL OF THORACIC ONCOLOGY, Vol: 9, Pages: 596-611, ISSN: 1556-0864
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- Citations: 191
Keir GJ, Maher TM, Ming D, et al., 2014, Rituximab in severe, treatment-refractory interstitial lung disease, RESPIROLOGY, Vol: 19, Pages: 353-359, ISSN: 1323-7799
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- Citations: 176
Ruffini E, Detterbeck F, Van Raemdonck D, et al., 2014, Thymic Carcinoma: A Cohort Study of Patients from the European Society of Thoracic Surgeons Database, JOURNAL OF THORACIC ONCOLOGY, Vol: 9, Pages: 541-548, ISSN: 1556-0864
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- Citations: 127
Bari MF, Brown H, Nicholson AG, et al., 2014, BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas, HISTOPATHOLOGY, Vol: 64, Pages: 547-556, ISSN: 0309-0167
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- Citations: 38
Walsh SLF, Wells AU, Sverzellati N, et al., 2014, An integrated clinicoradiological staging system for pulmonary sarcoidosis: a case-cohort study, The Lancet Respiratory Medicine, Vol: 2, Pages: 123-130, ISSN: 2213-2600
BackgroundMortality in pulmonary sarcoidosis is highly variable and a reliable prognostic algorithm for disease staging and for guiding management decisions is needed. The objective of this study is to derive and test a staging system for determining prognosis in pulmonary sarcoidosis.MethodsWe identified the prognostic value of high-resolution computed tomography (HRCT) patterns and pulmonary function tests, including the composite physiological index (CPI) in patients with pulmonary sarcoidosis. We integrated prognostic physiological and HRCT variables to form a clinical staging algorithm predictive of mortality in a test cohort. The staging system was externally validated in a separate cohort by the same methods of discrimination used in the primary analysis and tested for clinical applicability by four test observers.FindingsThe test cohort included 251 patients with pulmonary sarcoidosis in the study referred to the Sarcoidosis clinic at the Royal Brompton Hospital, UK, between Jan 1, 2000, and June 30, 2010. The CPI was the strongest predictor of mortality (HR 1·04, 95% CI 1·02–1·06, p<0·0001) in the test cohort. An optimal CPI threshold of 40 units was identified (HR 4·24, 2·84–6·33, p<0·0001). The CPI40, main pulmonary artery diameter to ascending aorta diameter ratio (MPAD/AAD), and an extent of fibrosis threshold of 20% were combined to form a staging algorithm. When assessed in the validation cohort (n=252), this staging system was strikingly more predictive of mortality than any individual variable alone (HR 5·89, 2·68–10·08, p<0·0001). The staging system was successfully applied to the test and validation cohorts combined, by two radiologists and two physicians.InterpretationA clear prognostic separation of patients with pulmonary sarcoidosis is provided by a simple staging system integrating the CPI and two HRCT variables.FundingNational Insti
Detterbeck FC, Nicholson AG, Kondo K, et al., 2014, [The Masaoka-Koga stage classification for thymic malignancies clarification and definition of terms]., Zhongguo Fei Ai Za Zhi, Vol: 17, Pages: 75-81
Montero-Fernandez MA, Osadolor T, Monforte V, et al., 2014, Restrictive Allograft Syndrome and Idiopathic Pleuropulmonary Fibroelastosis: Same Histology for Two Different Scenarios, 103rd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), Publisher: NATURE PUBLISHING GROUP, Pages: 488A-488A, ISSN: 0023-6837
Montero-Fernandez MA, Osadolor T, Monforte V, et al., 2014, Restrictive Allograft Syndrome and Idiopathic Pleuropulmonary Fibroelastosis: Same Histology for Two Different Scenarios, 103rd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), Publisher: NATURE PUBLISHING GROUP, Pages: 488A-488A, ISSN: 0893-3952
Freydina DV, Tay A, Chudasama D, et al., 2014, The ability of a filter-based antibody-independent approach to capture circulating tumour cells for the diagnosis of lung cancer, Publisher: ELSEVIER IRELAND LTD, Pages: S17-S18, ISSN: 0169-5002
Freidin MB, Mair D, Tay A, et al., 2014, The utility of peripheral blood circulating tumour cells for the detection of <i>KRAS</i>, <i>EGFR</i> and <i>BRAF</i> mutations in primary lung, Publisher: ELSEVIER IRELAND LTD, Pages: S3-S4, ISSN: 0169-5002
Rice A, My-Anh T-D, Bush A, et al., 2013, Diffuse lung disease in infancy and childhood: expanding the chILD classification, HISTOPATHOLOGY, Vol: 63, Pages: 743-755, ISSN: 0309-0167
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- Citations: 50
Datta A, Alexander R, Sulikowski MG, et al., 2013, Evidence for a Functional Thymic Stromal Lymphopoietin Signaling Axis in Fibrotic Lung Disease, JOURNAL OF IMMUNOLOGY, Vol: 191, Pages: 4867-4879, ISSN: 0022-1767
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- Citations: 50
Nicholson AG, 2013, SUBMIT YOUR CHALLENGING CASES FOR DISCUSSION & DEBATE!, JOURNAL OF THORACIC ONCOLOGY, Vol: 8, Pages: S94-S94, ISSN: 1556-0864
Pattenden H, Leung M, Beddow E, et al., 2013, TEST PERFORMANCE OF PET-CT FOR MEDIASTINAL LYMPH NODE STAGING OF PULMONARY CARCINOID TUMOURS, JOURNAL OF THORACIC ONCOLOGY, Vol: 8, Pages: S676-S677, ISSN: 1556-0864
Lim E, De Castro DG, Popat S, et al., 2013, FREQUENCY IN EGFR, K-RAS, BRAF AND ALK MUTATIONS IN A COHORT OF CANCERS: ALK TRANSLOCATIONS ARE MORE FREQUENTLY SEEN IN ADVANCED DISEASE, JOURNAL OF THORACIC ONCOLOGY, Vol: 8, Pages: S1222-S1223, ISSN: 1556-0864
Nicholson AG, 2013, SQUAMOUS CELL CARCINOMA, JOURNAL OF THORACIC ONCOLOGY, Vol: 8, Pages: S17-S18, ISSN: 1556-0864
Freidin MB, Mair D, Tay A, et al., 2013, THE EFFICIENCY OF DETECTION OF KRAS, EGFR AND BRAF MUTATIONS IN PRIMARY LUNG CANCER VIA PERIPHERAL BLOOD CIRCULATING TUMOUR CELLS, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S456-S456, ISSN: 1556-0864
Freydina DV, Tay A, Chudasama D, et al., 2013, DIAGNOSTIC PERFORMANCE OF A FILTER-BASED ANTIBODY-INDEPENDENT PERIPHERAL BLOOD CIRCULATING TUMOUR CELL CAPTURE PAIRED WITH CYTOMORPHOLOGIC CRITERIA FOR THE DIAGNOSIS OF LUNG CANCER, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S1278-S1278, ISSN: 1556-0864
Chana KK, Fenwick PS, Nicholson AG, et al., 2013, Identiļ¬cation of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease, Journal of Allergy and Clinical Immunology, ISSN: 0091-6749
BackgroundIn patients with chronic obstructive pulmonary disease (COPD), pulmonary macrophages increase in number, release increased levels of inflammatory mediators, and respond poorly to glucocorticosteroids. Whether this is due to a change in macrophage phenotype or localized activation is unknown.ObjectiveWe sought to investigate whether macrophages from patients with COPD are a distinct phenotype.MethodsMacrophage populations were isolated from human lung tissue from nonsmokers, smokers, and patients with COPD by using Percoll density gradients. Five macrophage populations were isolated on the basis of density (1.011-1.023, 1.023-1.036, 1.036-1.048, 1.048-1.061, and 1.061-1.073 g/mL), and cell-surface expression of CD14, CD16, CD163, CD40, and CD206 was assessed by using flow cytometry. Release of active matrix metalloproteinase 9, TNF-α, CXCL8, and IL-10 was measured by using ELISA.ResultsThe 2 least dense fractions were more than 90% apoptotic/necrotic, with the remaining fractions greater than 70% viable. Macrophages from nonsmokers and smokers were CD163+, CD206+, CD14+, and CD40−, whereas macrophages from patients with COPD were less defined, showing significantly lower expression of all receptors. There were no differences in receptor expression associated with density. Macrophages from patients with COPD of a density of 1.036 to 1.048 g/mL released higher levels of active matrix metalloproteinase 9 compared with cells from nonsmokers, with no difference between the remaining fractions. This population of macrophages from patients with COPD was less responsive to budesonide compared with those from nonsmokers and smokers when stimulated with LPS. Glucocorticosteroid insensitivity was selective for proinflammatory cytokines because budesonide inhibition of LPS-stimulated IL-10 release was similar for all macrophages.ConclusionsThis study identifies a specific macrophage phenotype in the lungs of patients with COPD who are glucocorticosteroid in
Bush A, Anthony G, Barbato A, et al., 2013, Research in progress: put the orphanage out of business, THORAX, Vol: 68, Pages: 971-973, ISSN: 0040-6376
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- Citations: 26
Abdullah R, Ming D, Keir G, et al., 2013, Rituximab in severe, treatment-refractory interstitial lung disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Kambouchner M, Levy P, Schubel K, et al., 2013, Prognostic relevance of histologic features in nonspecific interstitial pneumonia (NSIP), EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Shaw EC, Collins VP, de Castro DG, et al., 2013, Variation in Cellular Pathology Department Specimen Handling Processes in the Cancer Research UK Stratified Medicine Programme, 7th Joint Meeting of the British-Division of the International-Academy-of-Pathology and the Pathological-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 22-22, ISSN: 0022-3417
Iftikhar HK, Rice A, Montero A, et al., 2013, Evaluation of Cell Pellet Usage in Endobronchial Ultrasound-Guided Fine Needle Aspirations (EBUS-FNAS), 7th Joint Meeting of the British-Division of the International-Academy-of-Pathology and the Pathological-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 22-22, ISSN: 0022-3417
Lindahl GE, Stock CJW, Xu S-W, et al., 2013, Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease, Respiratory Research, Vol: 14, ISSN: 1465-9921
Background: Interstitial lung disease is a major cause of morbidity and mortality in systemic sclerosis (SSc), with insufficiently effective treatment options. Progression of pulmonary fibrosis involves expanding populations of fibroblasts, and the accumulation of extracellular matrix proteins. Characterisation of SSc lung fibroblast gene expression profiles underlying the fibrotic cell phenotype could enable a better understanding of the processes leading to the progressive build-up of scar tissue in the lungs. In this study we evaluate the transcriptomes of fibroblasts isolated from SSc lung biopsies at the time of diagnosis, compared with those from control lungs.Methods: We used Affymetrix oligonucleotide microarrays to compare the gene expression profile of pulmonary fibroblasts cultured from 8 patients with pulmonary fibrosis associated with SSc (SSc-ILD), with those from control lung tissue peripheral to resected cancer (n=10). Fibroblast cultures from 3 patients with idiopathic pulmonary fibrosis (IPF) were included as a further comparison. Genes differentially expressed were identified using two separate analysis programs following a set of pre-determined criteria: only genes significant in both analyses were considered. Microarray expression data was verified by qRT-PCR and/or western blot analysis.Results: A total of 843 genes were identified as differentially expressed in pulmonary fibroblasts from SSc-ILD and/or IPF compared to control lung, with a large overlap in the expression profiles of both diseases. We observed increased expression of a TGF-β response signature including fibrosis associated genes and myofibroblast markers, with marked heterogeneity across samples. Strongly suppressed expression of interferon stimulated genes, including antiviral, chemokine, and MHC class 1 genes, was uniformly observed in fibrotic fibroblasts. This expression profile includes key regulators and mediators of the interferon response, such as STAT1, and CXCL10
Nowak K, Karenovics W, Nicholson AG, et al., 2013, Pure bronchoplastic resections of the bronchus without pulmonary resection for endobronchial carcinoid tumours<SUP>†</SUP>, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Vol: 17, Pages: 291-294, ISSN: 1569-9293
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- Citations: 11
Lota HK, Keir GJ, Hansell DM, et al., 2013, Novel use of rituximab in hypersensitivity pneumonitis refractory to conventional treatment, THORAX, Vol: 68, ISSN: 0040-6376
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- Citations: 39
Jones KD, Churg A, Henderson DW, et al., 2013, Data Set for Reporting of Lung Carcinomas Recommendations From International Collaboration on Cancer Reporting, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, Vol: 137, Pages: 1054-1062, ISSN: 0003-9985
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- Citations: 20
Sykes A, Brooks T, Dusmet M, et al., 2013, Inhalational anthrax in a vaccinated soldier, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, Pages: 285-287, ISSN: 0903-1936
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- Citations: 5
Alrifai D, Popat S, Ahmed M, et al., 2013, A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations, LUNG CANCER, Vol: 80, Pages: 339-340, ISSN: 0169-5002
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- Citations: 17
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