Imperial College London
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Professor Anthony Gordon

Faculty of Medicine, Department of Surgery & Cancer

Chair in Anaesthesia and Critical Care
 
 
 
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Contact

 

anthony.gordon

 
 
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Location

 

ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mills:2015:cid/civ378,
author = {Mills, TC and Chapman, S and Hutton, P and Gordon, AC and Bion, J and Chiche, JD and Holloway, PA and Stüber, F and Garrard, CS and Hinds, CJ and Hill, AV and Rautanen, A and ESICMECCRN, GenOSept Investigators},
doi = {cid/civ378},
journal = {Clinical Infectious Diseases},
pages = {695--703},
title = {Variants in the mannose-binding lectin gene MBL2 do not associate with sepsis susceptibility or survival in a large European cohort},
url = {http://dx.doi.org/10.1093/cid/civ378},
volume = {61},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND:  Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from sepsis for variants in the functionally important immune-related gene MBL2. These studies have largely been underpowered and contradictory. METHODS:  We genotyped and analysed four important MBL2 SNPs (rs5030737, rs1800450, rs1800451 and rs7096206) in 1839 European community-acquired pneumonia (CAP) and peritonitis sepsis cases, and 477 controls from the UK. We analysed the following predefined subgroups and outcomes: 28-day and 6 month mortality from sepsis due to CAP or peritonitis combined, 28-day mortality from CAP sepsis, peritonitis sepsis, pneumococcal sepsis or sepsis in younger patients, and susceptibility to CAP sepsis or pneumococcal sepsis in the UK. RESULTS:  There were no significant associations (all p-values were greater than 0.05 after correction for multiple testing) between MBL2 genotypes and any of our predefined analyses. CONCLUSIONS:  In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.
AU  - Mills,TC
AU  - Chapman,S
AU  - Hutton,P
AU  - Gordon,AC
AU  - Bion,J
AU  - Chiche,JD
AU  - Holloway,PA
AU  - Stüber,F
AU  - Garrard,CS
AU  - Hinds,CJ
AU  - Hill,AV
AU  - Rautanen,A
AU  - ESICMECCRN,GenOSept Investigators
DO  - cid/civ378
EP  - 703
PY  - 2015///
SN  - 1537-6591
SP  - 695
TI  - Variants in the mannose-binding lectin gene MBL2 do not associate with sepsis susceptibility or survival in a large European cohort
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/civ378
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25969530
UR  - http://hdl.handle.net/10044/1/23416
VL  - 61
ER  -
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