Imperial College London
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DrBiancastellaCereser

Faculty of Medicine, Department of Surgery & Cancer

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 2822b.cereser Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lavery:2015:10.1136/gutjnl-2015-310748,
author = {Lavery, DL and Martinez, P and Gay, LJ and Cereser, B and Novelli, MR and Rodriguez-Justo, M and Meijer, SL and Graham, TA and McDonald, SA and Wright, NA and Jansen, M},
doi = {10.1136/gutjnl-2015-310748},
journal = {Gut},
pages = {907--913},
title = {Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus},
url = {http://dx.doi.org/10.1136/gutjnl-2015-310748},
volume = {65},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Barrett's oesophagus commonly presents as a patchwork of columnar metaplasia with and without goblet cells in the distal oesophagus. The presence of metaplastic columnar epithelium with goblet cells on oesophageal biopsy is a marker of cancer progression risk, but it is unclear whether clonal expansion and progression in Barrett's oesophagus is exclusive to columnar epithelium with goblet cells. DESIGN: We developed a novel method to trace the clonal ancestry of an oesophageal adenocarcinoma across an entire Barrett's segment. Clonal expansions in Barrett's mucosa were identified using cytochrome c oxidase enzyme histochemistry. Somatic mutations were identified through mitochondrial DNA sequencing and single gland whole exome sequencing. RESULTS: By tracing the clonal origin of an oesophageal adenocarcinoma across an entire Barrett's segment through a combination of histopathological spatial mapping and clonal ordering, we find that this cancer developed from a premalignant clonal expansion in non-dysplastic ('cardia-type') columnar metaplasia without goblet cells. CONCLUSION: Our data demonstrate the premalignant potential of metaplastic columnar epithelium without goblet cells in the context of Barrett's oesophagus.
AU  - Lavery,DL
AU  - Martinez,P
AU  - Gay,LJ
AU  - Cereser,B
AU  - Novelli,MR
AU  - Rodriguez-Justo,M
AU  - Meijer,SL
AU  - Graham,TA
AU  - McDonald,SA
AU  - Wright,NA
AU  - Jansen,M
DO  - 10.1136/gutjnl-2015-310748
EP  - 913
PY  - 2015///
SN  - 1468-3288
SP  - 907
TI  - Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus
T2  - Gut
UR  - http://dx.doi.org/10.1136/gutjnl-2015-310748
UR  - http://hdl.handle.net/10044/1/39947
VL  - 65
ER  -
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