Imperial College London
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DrBrianHalliday

Faculty of Medicine, National Heart & Lung Institute

Sr Lecturer Cardiomyopathy Cardiovascular Magnetic Resonance
 
 
 
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b.halliday

 
 
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Location

 

Cardiovascular MR UnitRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Loudon:2018:10.1038/s41598-018-32738-y,
author = {Loudon, B and Ntatsaki, E and Newsome, S and Halliday, BP and Lota, A and Ali, A and Malley, T and Selvendran, S and Aggarwal, N and Lam, W and Donovan, J and Auger, D and Raphael, C and Flynn, P and Pennell, D and Vassiliou, V and Prasad, S},
doi = {10.1038/s41598-018-32738-y},
journal = {Scientific Reports},
title = {Osteoprotegerin and myocardial fibrosis in patients with aortic stenosis},
url = {http://dx.doi.org/10.1038/s41598-018-32738-y},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Left ventricular myocardial fibrosis in patients with aortic stenosis (AS) confers worse prognosis. Plasma osteoprotegerin (OPG), a cytokine from the TNF receptor family, correlates with the degree of valve calcification in AS, reflecting the activity of the tissue RANKL/RANK/OPG (receptor activator of nuclear factor κΒ ligand/RANK/osteoprotegerin) axis, and is associated with poorer outcomes in AS. Its association with myocardial fibrosis is unknown. We hypothesised that OPG levels would reflect the extent of myocardial fibrosis in AS. We included 110 consecutive patients with AS who had undergone late-gadolinium contrast enhanced cardiovascular magnetic resonance (LGE-CMR). Patients were characterised according to pattern of fibrosis (no fibrosis, midwall fibrosis, or chronic myocardial infarction fibrosis). Serum OPG was measured with ELISA and compared between groups defined by valve stenosis severity. Some 36 patients had no fibrosis, 38 had midwall fibrosis, and 36 had chronic infarction. Patients with midwall fibrosis did not have higher levels of OPG compared to those without fibrosis (6.78 vs. 5.25 pmol/L, p = 0.12). There was no difference between those with midwall or chronic myocardial infarction fibrosis (6.78 vs. 6.97 pmol/L, p = 0.27). However, OPG levels in patients with chronic myocardial infarction fibrosis were significantly higher than those without fibrosis (p = 0.005).
AU  - Loudon,B
AU  - Ntatsaki,E
AU  - Newsome,S
AU  - Halliday,BP
AU  - Lota,A
AU  - Ali,A
AU  - Malley,T
AU  - Selvendran,S
AU  - Aggarwal,N
AU  - Lam,W
AU  - Donovan,J
AU  - Auger,D
AU  - Raphael,C
AU  - Flynn,P
AU  - Pennell,D
AU  - Vassiliou,V
AU  - Prasad,S
DO  - 10.1038/s41598-018-32738-y
PY  - 2018///
SN  - 2045-2322
TI  - Osteoprotegerin and myocardial fibrosis in patients with aortic stenosis
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-32738-y
UR  - http://hdl.handle.net/10044/1/64535
VL  - 8
ER  -
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