Imperial College London
Alternate

DrBrianRobertson

Faculty of Medicine, Department of Infectious Disease

Reader in Systems Microbiology
 
 
 
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Contact

 

b.robertson

 
 
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Location

 

3.41Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gordon:2023:10.12688/wellcomeopenres.18767.1,
author = {Gordon, SB and Sichone, S and Chirwa, AE and Hazenberg, P and Kafuko, Z and Ferreira, DM and Flynn, J and Fortune, S and Balasingam, S and Biagini, GA and McShane, H and Mwandumba, HC and Jambo, K and Dedha, K and Raj, Sharma N and Robertson, BD and Walker, NF and Morton, B},
doi = {10.12688/wellcomeopenres.18767.1},
journal = {Wellcome Open Research},
pages = {71--71},
title = {Practical considerations for a TB controlled human infection model (TB-CHIM); the case for TB-CHIM in Africa, a systematic review of the literature and report of 2 workshop discussions in UK and Malawi},
url = {http://dx.doi.org/10.12688/wellcomeopenres.18767.1},
volume = {8},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <ns4:p><ns4:bold>Background:</ns4:bold> Tuberculosis (TB) remains a major challenge in many domains including diagnosis, pathogenesis, prevention, treatment, drug resistance and long-term protection of the public health by vaccination. A controlled human infection model (CHIM) could potentially facilitate breakthroughs in each of these domains but has so far been considered impossible owing to technical and safety concerns.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> A systematic review of mycobacterial human challenge studies was carried out to evaluate progress to date, best possible ways forward and challenges to be overcome. We searched MEDLINE (1946 to current) and CINAHL (1984 to current) databases; and Google Scholar to search citations in selected manuscripts. The final search was conducted 3<ns4:sup>rd </ns4:sup>February 2022. Inclusion criteria: adults ≥18 years old; administration of live mycobacteria; and interventional trials or cohort studies with immune and/or microbiological endpoints. Exclusion criteria: animal studies; studies with no primary data; no administration of live mycobacteria; retrospective cohort studies; case-series; and case-reports. Relevant tools (Cochrane Collaboration for RCTs and Newcastle-Ottawa Scale for non-randomised studies) were used to assess risk of bias and present a narrative synthesis of our findings.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> The search identified 1,388 titles for review; of these 90 were reviewed for inclusion; and 27 were included. Of these, 15 were randomised controlled trials and 12 were prospective cohort studies. We focussed on administration route, challenge agent and dose administered for data extraction. Overall, BCG studies including fluorescent BCG show the most immediate utility, and genetically modified <ns4:italic>Mycobacteria tuberculosis</ns4:italic> is the most tantalising prospect of disco
AU  - Gordon,SB
AU  - Sichone,S
AU  - Chirwa,AE
AU  - Hazenberg,P
AU  - Kafuko,Z
AU  - Ferreira,DM
AU  - Flynn,J
AU  - Fortune,S
AU  - Balasingam,S
AU  - Biagini,GA
AU  - McShane,H
AU  - Mwandumba,HC
AU  - Jambo,K
AU  - Dedha,K
AU  - Raj,Sharma N
AU  - Robertson,BD
AU  - Walker,NF
AU  - Morton,B
DO  - 10.12688/wellcomeopenres.18767.1
EP  - 71
PY  - 2023///
SP  - 71
TI  - Practical considerations for a TB controlled human infection model (TB-CHIM); the case for TB-CHIM in Africa, a systematic review of the literature and report of 2 workshop discussions in UK and Malawi
T2  - Wellcome Open Research
UR  - http://dx.doi.org/10.12688/wellcomeopenres.18767.1
VL  - 8
ER  -
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