Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mo:2021:10.1371/journal.pmed.1003816,
author = {Mo, Y and Eyre, DW and Lumley, SF and Walker, TM and Shaw, RH and O'Donnell, D and Butcher, L and Jeffery, K and Donnelly, CA and Oxford, COVID infection review team and Cooper, BS},
doi = {10.1371/journal.pmed.1003816},
journal = {PLoS Medicine},
title = {Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study},
url = {http://dx.doi.org/10.1371/journal.pmed.1003816},
volume = {18},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Nosocomial spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been widely reported, but the transmission pathways among patients and healthcare workers (HCWs) are unclear. Identifying the risk factors and drivers for these nosocomial transmissions is critical for infection prevention and control interventions. The main aim of our study was to quantify the relative importance of different transmission pathways of SARS-CoV-2 in the hospital setting. METHODS AND FINDINGS: This is an observational cohort study using data from 4 teaching hospitals in Oxfordshire, United Kingdom, from January to October 2020. Associations between infectious SARS-CoV-2 individuals and infection risk were quantified using logistic, generalised additive and linear mixed models. Cases were classified as community- or hospital-acquired using likely incubation periods of 3 to 7 days. Of 66,184 patients who were hospitalised during the study period, 920 had a positive SARS-CoV-2 PCR test within the same period (1.4%). The mean age was 67.9 (±20.7) years, 49.2% were females, and 68.5% were from the white ethnic group. Out of these, 571 patients had their first positive PCR tests while hospitalised (62.1%), and 97 of these occurred at least 7 days after admission (10.5%). Among the 5,596 HCWs, 615 (11.0%) tested positive during the study period using PCR or serological tests. The mean age was 39.5 (±11.1) years, 78.9% were females, and 49.8% were nurses. For susceptible patients, 1 day in the same ward with another patient with hospital-acquired SARS-CoV-2 was associated with an additional 7.5 infections per 1,000 susceptible patients (95% credible interval (CrI) 5.5 to 9.5/1,000 susceptible patients/day) per day. Exposure to an infectious patient with community-acquired Coronavirus Disease 2019 (COVID-19) or to an infectious HCW was associated with substantially lower infection risks (2.0/1,000 susceptible patients/day, 95% CrI 1.6 to 2.2). As for
AU  - Mo,Y
AU  - Eyre,DW
AU  - Lumley,SF
AU  - Walker,TM
AU  - Shaw,RH
AU  - O'Donnell,D
AU  - Butcher,L
AU  - Jeffery,K
AU  - Donnelly,CA
AU  - Oxford,COVID infection review team
AU  - Cooper,BS
DO  - 10.1371/journal.pmed.1003816
PY  - 2021///
SN  - 1549-1277
TI  - Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study
T2  - PLoS Medicine
UR  - http://dx.doi.org/10.1371/journal.pmed.1003816
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34637439
UR  - http://hdl.handle.net/10044/1/92149
VL  - 18
ER  -
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