Publications
414 results found
Lueck H, Ewald-Riegler N, De Gregorio N, et al., 2012, A SEMI-PROSPECTIVE TRIAL TO DETERMINE THE OUTCOME OF BORDERLINE OVARIAN TUMOR PATIENTS. RESULTS OF ROBOT, A STUDY OF THE AGO STUDY GROUP, 37th Congress of the European-Society-for-Medical-Oncology (ESMO), Publisher: OXFORD UNIV PRESS, Pages: 322-322, ISSN: 0923-7534
Sehouli J, Runnebaum IB, Fotopoulou C, et al., 2012, A randomized phase III adjuvant study in high-risk cervical cancer: simultaneous radiochemotherapy with cisplatin (S-RC) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R): a NOGGO-AGO Intergroup Study., Ann Oncol, Vol: 23, Pages: 2259-2264
BACKGROUND: Simultaneous adjuvant platinum-based radiochemotherapy in high-risk cervical cancer (CC) is an established treatment strategy. Sequential paclitaxel (Taxol) and platinum followed by radiotherapy may offer further advantages regarding toxicity. PATIENTS AND METHODS: An open-labeled randomized phase III trial was conducted to compare paclitaxel (175 mg/m2) plus carboplatin (AUC5) followed by radiation (50.4 Gy) (experimental arm-A) versus simultaneous radiochemotherapy with cisplatin (40 mg/m2/week) (arm-B) in patients with stage IB-IIB CC after surgery. Primary objective was progression-free survival (PFS). RESULTS: Overall, 271 patients were randomized and 263 were eligible for evaluation; 132 in arm-A and 131 in arm-B appropriately balanced. The estimated 2-year PFS was 81.8% [95% confidence interval (CI) 74.4-89.1] in arm-B versus 87.2% (95% CI 81.2-93.3) in arm-A (P=0.235) and the corresponding 5-year survival rates were 85.8% in arm-A and 78.9% in arm-B (P=0.25). Hematological grade 3/4 toxicity was higher in arm-B. Alopecia (87.9% versus 4.1%; P<0.001) and neurotoxicity (65.9% versus 15.6%; P<0.001) were significantly higher in arm-A. Early treatment termination was significantly more frequent in arm-B than in arm-A (32.1% versus 12.9%; P=0.001). CONCLUSIONS: Sequential chemotherapy and radiation in high-risk CC could not show any significant survival benefit; however, a different toxicity profile appeared. This sequential regime may constitute an alternative option when contraindications for immediate postoperative radiation are present.
Bamberg C, Fotopoulou C, Neissner P, et al., 2012, Maternal characteristics and twin gestation outcomes over 10 years: impact of conception methods, FERTILITY AND STERILITY, Vol: 98, ISSN: 0015-0282
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- Citations: 26
Schmalfeldt B, Burges A, Hilpert F, et al., 2012, Disease Progression in female Patients with borderline ovarian Tumors: Results of the multicentric AGO 'ROBOT' Study, Publisher: GEORG THIEME VERLAG KG, Pages: P15-P15, ISSN: 0016-5751
Bamberg C, Fotopoulou C, Thiem D, et al., 2012, Correlation of midtrimester amniotic fluid cytokine concentrations with adverse pregnancy outcome in terms of spontaneous abortion, preterm birth, and preeclampsia, JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 25, Pages: 812-817, ISSN: 1476-7058
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- Citations: 20
Braicu I, Chekerov R, Richter R, et al., 2012, Use of HE4 and CA125 to predict surgical outcome and for prognostic value for progression-free survival (PFS) and overall survival (OS) in primary epithelial ovarian cancer (EOC) patients (pts), 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Ruscito I, Braicu EI, Panici PB, et al., 2012, BRCA1 methylation status in high-grade serous ovarian cancer (HGSOC) patients (pts)., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
De Gregorio N, Baumann KH, Keyver-Paik M-D, et al., 2012, Outcome of patients with borderline ovarian tumors: Results of the multicenter AGO ROBOT study., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
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- Citations: 2
Pietzner K, Chekerov R, Reinthaller A, et al., 2012, A matched pair analysis of intra- and postoperative catumaxomab in patients with ovarian cancer from a multicenter, single-arm phase II trial versus a consecutive single-center collective of ovarian cancer patients without immunotherapy., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
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- Citations: 1
Woopen H, Pietzner K, Richter R, et al., 2012, Prognostic value of epithelial cell adhesion molecule (EpCAM) in patients with primary epithelial ovarian cancer., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Chekerov R, Braicu I, Harter P, et al., 2012, Recurrent ovarian cancer and management of elderly patients: Results of a prospective trial of treosulfan focusing on patient's preference and clinical outcome (NOGGO-Preference-Study), 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Vasconcelos I, Olek S, Gellhaus K, et al., 2012, Effect of tumor-infiltrating T-lymphocytes on the aggressiveness of epithelial ovarian tumors., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Fotopoulou C, Braicu I, Vergote IB, et al., 2012, Interval versus primary tumor debulking surgery in advanced ovarian cancer: Analysis of the European OVCAD data, 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
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- Citations: 1
Kraetschell RW, Fotopoulou C, Dowdy SC, et al., 2012, How is the current clinical management of endometrial cancer worldwide? An international survey by the North-Eastern German Society of Gynaecological Oncology (NOGGO)., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Pilger A, Richter R, Fotopoulou C, et al., 2012, Effects of cancer therapy on sexuality and quality of life (QoL) of patients with gynecologic malignancies (GM): Results from 55 pts., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Kessler M, Fotopoulou C, Winsauer C, et al., 2012, Identification of the stem cells in the epithelium of human Fallopian tube, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472
Sehouli J, Papanikolaou G, Braicu E-I, et al., 2012, Feasibility of Surgery After Systemic Treatment with the Humanized Recombinant Antibody Bevacizumab in Heavily Pretreated Patients with Advanced Epithelial Ovarian Cancer, ANNALS OF SURGICAL ONCOLOGY, Vol: 19, Pages: 1326-1333, ISSN: 1068-9265
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- Citations: 9
Braicu E-I, Sehouli J, Richter R, et al., 2012, Primary versus secondary cytoreduction for epithelial ovarian cancer: A paired analysis of tumour pattern and surgical outcome, EUROPEAN JOURNAL OF CANCER, Vol: 48, Pages: 687-694, ISSN: 0959-8049
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- Citations: 17
Tian W-J, Chi DS, Sehouli J, et al., 2012, A Risk Model for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer: An Evidence-Based Proposal for Patient Selection, ANNALS OF SURGICAL ONCOLOGY, Vol: 19, Pages: 597-604, ISSN: 1068-9265
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- Citations: 89
Bamberg C, Scheuermann S, Fotopoulou C, et al., 2012, Angle of progression measurements of fetal head at term: a systematic comparison between open magnetic resonance imaging and transperineal ultrasound, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, Vol: 206, ISSN: 0002-9378
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- Citations: 12
Kessler M, Zielecki J, Thieck O, et al., 2012, <i>Chlamydia trachomatis</i> Disturbs Epithelial Tissue Homeostasis in Fallopian Tubes via Paracrine Wnt Signaling, AMERICAN JOURNAL OF PATHOLOGY, Vol: 180, Pages: 186-198, ISSN: 0002-9440
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- Citations: 55
Fotopoulou C, Braicu I, Sehouli J, 2012, Fertility-sparing surgery in early epithelial ovarian cancer: a viable option?, Obstet Gynecol Int, Vol: 2012
Epithelial ovarian cancer (EOC) continues to represent one of the most lethal conditions in women in the western countries. With the shifting of childbearing towards higher age, EOC increasingly affects women with active childbearing wish, resulting in major impacts on treatment management. Next to the optimal therapeutic treatment strategies, gynecologic oncologists are being asked to incorporate into their decision-making processes the patients' wish for fertility preserving alternatives ideally without compromising oncologic safety. Nowadays, fertility-sparing surgery represents an effective alternative to conventional radical cytoreduction in younger women with early stages of the disease. As such, this paper considers indications for fertility sparing surgery in EOC, reflects on outcomes from the oncologic and reproductive data of the largest and most relevant series outcomes data, reporting on fertility sparing techniques in EOC, reviews medicamentous efforts to prevent chemotherapy induced gonadotoxicity, and discusses future aspects in the gynecologic cancer management.
Braicu E-I, Sehouli J, Richter R, et al., 2011, Role of histological type on surgical outcome and survival following radical primary tumour debulking of epithelial ovarian, fallopian tube and peritoneal cancers, BRITISH JOURNAL OF CANCER, Vol: 105, Pages: 1818-1824, ISSN: 0007-0920
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- Citations: 47
Zang RY, Harter P, Chi DS, et al., 2011, Predictors of survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery based on the pooled analysis of an international collaborative cohort, BRITISH JOURNAL OF CANCER, Vol: 105, Pages: 890-896, ISSN: 0007-0920
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- Citations: 89
Fotopoulou C, Richter R, Braicu E-I, et al., 2011, Impact of Obesity on Operative Morbidity and Clinical Outcome in Primary Epithelial Ovarian Cancer after Optimal Primary Tumor Debulking, ANNALS OF SURGICAL ONCOLOGY, Vol: 18, Pages: 2629-2637, ISSN: 1068-9265
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- Citations: 28
Braicu E, Atz J, Dettmar K, et al., 2011, Immune effector cells from ovarian cancer patients undergoing standard chemotherapy can be activated by catumaxomab for efficient killing of epithelial tumor cells, Publisher: KARGER, Pages: 222-222, ISSN: 0378-584X
Papanikolaou G, Fotopoulou C, Braicu I, et al., 2011, First Surgical Experience of Intraperitoneal Treatment with the Trifunctional Antibody Catumaxomab (Anti-EpCam x Anti-CD3) for Epithelial Ovarian Cancer, ANTICANCER RESEARCH, Vol: 31, Pages: 2603-2608, ISSN: 0250-7005
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- Citations: 4
Gil-Ibanez B, Oskay-Oezcelik G, Richter R, et al., 2011, Predictive Factors in Relapsed Ovarian Cancer for Complete Tumor Resection, ANTICANCER RESEARCH, Vol: 31, Pages: 2583-2587, ISSN: 0250-7005
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- Citations: 4
Fotopoulou C, Sehouli J, Pschowski R, et al., 2011, Systemic Changes of Tryptophan Catabolites <i>via</i> the Indoleamine-2,3-dioxygenase Pathway in Primary Cervical Cancer, ANTICANCER RESEARCH, Vol: 31, Pages: 2629-2635, ISSN: 0250-7005
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- Citations: 18
Pietzner K, Schmuck RB, Fotopoulou C, et al., 2011, Long Term Combination Treatment With Bevacizumab, Pegylated Liposomal Doxorubicin and Regional Abdominal Hyperthermia in Platinum Refractory Ovarian Cancer: A Case Report and Review of the Literature, ANTICANCER RESEARCH, Vol: 31, Pages: 2675-2677, ISSN: 0250-7005
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- Citations: 6
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